TRIM8 and USP39

Number of citations of the paper that reports this interaction (PubMedID 23105109)
16

Data Source:
BioGRID (two hybrid)

		TRIM8	USP39
Description		tripartite motif containing 8	ubiquitin specific peptidase 39
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol PML Body	Nucleus Nucleoplasm Spliceosomal Complex U4/U6 X U5 Tri-snRNP Complex
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Protein Homodimerization Activity	Protein Binding Zinc Ion Binding Thiol-dependent Ubiquitinyl Hydrolase Activity
	Biological Process	Positive Regulation Of Autophagy Protein Ubiquitination Stem Cell Population Maintenance Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Viral Release From Host Cell	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing Cell Cycle RNA Splicing Protein Deubiquitination Cell Division
Pathways		Interferon gamma signaling	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Feeling nervous ( 29500382) Prostate cancer ( 23535732) Pulse pressure ( 30578418) Schizophrenia ( 25056061 30285260) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 26192919) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Neurofibrillary tangles ( 31497858)
Interacting Genes		46 interacting genes: BRAP CBL CCNH ITSN1 MAGEC2 MKRN3 MSL2 OTUB2 PCGF5 RAD18 RC3H2 RCHY1 RNF111 RNF113A RNF138 RNF141 RNF181 RNF41 RNF7 SIAH1 SOCS1 TICAM1 TNFAIP3 TRAF5 TRIM15 TRIM2 TRIM21 TRIM24 TRIM25 TRIM39 TRIM43 TRIM47 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L6 UBE2V1 UBE2W UHRF2 USP2 USP21 USP39 USP7 XIAP	13 interacting genes: ACVR1 APP LRRK2 SAE1 SP1 SRPK1 SRPK2 TRAF6 TRIM25 TRIM26 TRIM39 TRIM5 TRIM8
Entrez ID		81603	10713
HPRD ID		06934	07165
Ensembl ID		ENSG00000171206	ENSG00000168883
Uniprot IDs		Q9BZR9	A0A087X1B2 B3KMG1 B3KPG7 B7Z7L9 Q53GS9
PDB IDs			3JCR 6AH0 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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