HMGA2 and SYNCRIP

Number of citations of the paper that reports this interaction (PubMedID 18850631)
11

Data Source:
BioGRID (far western blotting)

		HMGA2	SYNCRIP
Description		high mobility group AT-hook 2	synaptotagmin binding cytoplasmic RNA interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Nucleus Nucleoplasm Protein-DNA Complex Senescence-associated Heterochromatin Focus SMAD Protein Complex	Nucleus Nucleoplasm Endoplasmic Reticulum Membrane CRD-mediated MRNA Stability Complex Catalytic Step 2 Spliceosome Histone Pre-mRNA 3'end Processing Complex GAIT Complex Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding AT DNA Binding Transcription Coregulator Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding Transcription Factor Binding DNA Binding, Bending Nucleosomal DNA Binding CAMP Response Element Binding MH2 Domain Binding MH1 Domain Binding Transcription Regulatory Region DNA Binding SMAD Binding 5'-deoxyribose-5-phosphate Lyase Activity C2H2 Zinc Finger Domain Binding	RNA Binding MRNA Binding Protein Binding Poly(A) Binding MRNA 5'-UTR Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Epithelial To Mesenchymal Transition Chondrocyte Differentiation Mesodermal-endodermal Cell Signaling Base-excision Repair Chromatin Organization Regulation Of Transcription, DNA-templated Mitotic G2 DNA Damage Checkpoint Multicellular Organism Development Response To Virus Regulation Of Cell Cycle Process Positive Regulation Of Gene Expression Chromosome Condensation Chromosome Breakage Heterochromatin Assembly Histone H2A-S139 Phosphorylation Senescence-associated Heterochromatin Focus Assembly Endodermal Cell Differentiation Chondrocyte Proliferation Regulation Of Growth DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation By Host Of Viral Transcription Fat Cell Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Mesodermal Cell Differentiation Mesenchymal Cell Differentiation Stem Cell Differentiation Cell Division Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Cell Proliferation In Bone Marrow Positive Regulation Of Protein Serine/threonine Kinase Activity Oncogene-induced Cell Senescence Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Cellular Response To X-ray Negative Regulation Of Cellular Senescence Positive Regulation Of Cellular Senescence Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Cellular Response To Drug	MRNA Splicing, Via Spliceosome Osteoblast Differentiation RNA Processing RNA Splicing Viral Process Negative Regulation Of Translation CRD-mediated MRNA Stabilization Cellular Response To Interferon-gamma
Pathways		Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Adverse response to drug ( 30420678) Aortic root size ( 19584346) Axial length ( 24144296) Birth length ( 25281659) Birth weight ( 23202124 31043758 27680694) Brain structure ( 22504417) Chin dimples ( 27182965) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Head circumference (infant) ( 22504419) Heart rate response to exercise ( 29769521) Heel bone mineral density ( 30598549) Height ( 21998595 28552196 20881960 22021425 25282103 25429064 19343178 23563607 31562340 18391950 18391951 18391952 20397748 17767157) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Infant length ( 25281659) Late-onset Alzheimer's disease ( 27770636) Medication use (drugs used in diabetes) ( 31015401) Offspring birth weight ( 31043758) Permanent tooth development ( 21931568) Polycystic ovary syndrome ( 22885925) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Type 2 diabetes ( 22885922 24509480 30054458 26961502 29358691 25102180 30297969 20581827 28869590) Type 2 diabetes nephropathy ( 21150874) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412)
Interacting Genes		21 interacting genes: APEX1 CDK1 CSNK2A1 CSNK2A2 E4F1 MDM2 NFKB1 NPM1 PA2G4 PCBP2 PIAS3 PRKCA PRMT6 PSIP1 PTBP1 RB1 RELA SMAD3 SYNCRIP TP53 XRCC6	31 interacting genes: A1CF APOBEC1 APP CSDE1 EPRS1 ESR1 GRB2 HABP4 HMGA1 HMGA2 HNRNPD HNRNPK IL7R INSR IVNS1ABP KLHL3 NUPR1 PABPC1 PCSK7 PLCG1 PRMT1 PTPN11 SMN1 SYT1 SYT11 SYT2 SYT3 SYT4 SYT7 SYT8 SYT9
Entrez ID		8091	10492
HPRD ID		02827	06734
Ensembl ID		ENSG00000149948	ENSG00000135316
Uniprot IDs		F5H2A4 F5H6H0 P52926 Q1M183	B7Z645 O60506 Q59GL1
PDB IDs			2DGU 2MXT 2NBB
Enriched GO Terms of Interacting Partners?
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