YEATS4 and MLLT10

Number of citations of the paper that reports this interaction (PubMedID 11756182)
28

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro, two hybrid)

		YEATS4	MLLT10
Description		YEATS domain containing 4	MLLT10 histone lysine methyltransferase DOT1L cofactor
Image
GO Annotations	Cellular Component	Nucleoplasm Nuclear Matrix Nuclear Membrane NuA4 Histone Acetyltransferase Complex	Nucleus Nucleoplasm Cytosol Protein-containing Complex
	Molecular Function	DNA Binding DNA-binding Transcription Factor Activity Structural Constituent Of Cytoskeleton Protein Binding Protein C-terminus Binding	DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Nucleosome Binding Histone Binding Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Cytoskeleton Organization Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Positive Regulation Of Transcription By RNA Polymerase II
Pathways		HATs acetylate histones Activation of the TFAP2 (AP-2) family of transcription factors
Drugs
Diseases
GWAS		Complete remission in asthma ( 29786918) Depressive symptoms x independent stressful life events interaction (1df test) ( 30718454) Height ( 31562340 18391951) Metabolite levels ( 23823483) Response to antidepressants (symptom remission) ( 29160301) Response to diuretic therapy ( 18591461) Response to SSRI in MDD or conscientiouness ( 29559929)	Breast cancer ( 23535729) Epithelial ovarian cancer ( 25581431) Gallstone disease ( 30504769) Hand grip strength ( 29691431) Lateral ventricular volume in normal aging ( 30258056) Meningioma ( 21804547) Metabolic syndrome ( 31589552) Multiple sclerosis ( 31604244) Multisite chronic pain ( 31194737) Ovarian cancer ( 23535730) Subcutaneous adipose tissue ( 26480920) Urinary albumin-to-creatinine ratio ( 31630189) Urinary sodium excretion ( 31409800)
Interacting Genes		13 interacting genes: CEP162 FRMD4A H3C1 MLLT10 MRGBP MYCN NUMA1 PFDN1 RNF8 SMARCB1 TACC1 TACC2 TFAP2B	7 interacting genes: DISC1 DOT1L MLLT1 NDEL1 RGPD5 SS18 YEATS4
Entrez ID		8089	8028
HPRD ID		03666	03874
Ensembl ID		ENSG00000127337	ENSG00000078403
Uniprot IDs		F8W0J4 O95619	P55197 Q59EQ6 Q6N002
PDB IDs		5VNA 5VNB 5XTZ 5Y8V	5DAG 5DAH 6CKN 6CKO 6JN2
Enriched GO Terms of Interacting Partners?
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