USP5 and CACNA1H

Number of citations of the paper that reports this interaction (PubMedID 25889575)
18

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		USP5	CACNA1H
Description		ubiquitin specific peptidase 5	calcium voltage-gated channel subunit alpha1 H
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Cytosol	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Calcium Channel Complex Integral Component Of Membrane Neuron Projection
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Ubiquitin Binding	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Cation Channel Activity Protein Binding Low Voltage-gated Calcium Channel Activity Metal Ion Binding Scaffold Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination	Muscle Contraction Muscle Organ Development Myoblast Fusion Regulation Of Heart Contraction Neuronal Action Potential Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Cortisol Biosynthetic Process Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Cellular Response To Potassium Ion Regulation Of Membrane Potential Positive Regulation Of Calcium Ion-dependent Exocytosis Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential Inorganic Cation Transmembrane Transport Positive Regulation Of Acrosome Reaction
Pathways		Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes	NCAM1 interactions
Drugs			Isradipine Spironolactone Cinnarizine Zonisamide Felodipine Nitrendipine Nifedipine Amiodarone Bepridil Mibefradil Flunarizine Trimebutine Manidipine
Diseases
GWAS			Blood protein levels ( 28240269)
Interacting Genes		23 interacting genes: APP CACNA1H DAZAP2 DVL2 PJA1 PLA2G2A RFFL RNF11 SMURF1 STK33 TADA3 TMEM239 TRAF6 TRIM26 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIML1 UBE2S UBTD2 USP28	3 interacting genes: GNG2 KCNMA1 USP5
Entrez ID		8078	8912
HPRD ID		03265	07442
Ensembl ID		ENSG00000111667	ENSG00000196557
Uniprot IDs		A0A140VJZ1 P45974	A0A1W2PQW2 B3KQH9 O95180
PDB IDs		2DAG 2DAK 2G43 2G45 3IHP 6DXH 6DXT 6NFT 6P9G
Enriched GO Terms of Interacting Partners?
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