SRCIN1 and SORBS3

Number of citations of the paper that reports this interaction (PubMedID 18662323)
8

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SRCIN1	SORBS3
Description		SRC kinase signaling inhibitor 1	sorbin and SH3 domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Focal Adhesion Postsynaptic Density Actin Cytoskeleton Lamellipodium Filopodium Axon Dendrite Neuronal Cell Body Synapse Presynapse	Nucleus Cytosol Cytoskeleton Focal Adhesion
	Molecular Function	Protein Binding Protein Kinase Binding Protein Domain Specific Binding	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding
	Biological Process	Exocytosis Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Protein Secretion Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Protein Tyrosine Kinase Activity	Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly
Pathways			Smooth Muscle Contraction
Drugs
Diseases
GWAS		Rate of ventricular enlargement ( 31711042)	Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)
Interacting Genes		6 interacting genes: ABL1 BCAR1 FBXO7 SNAP25 SORBS3 SRC	46 interacting genes: ABL1 ADAM15 ADAMTSL4 ARNT2 CBLB CPEB2 CPNE2 CPSF7 DDX17 DIP2A DLG5 DMRTB1 DVL2 EFS EIF3H FASLG FLOT1 HNRNPK HNRNPUL1 INPPL1 KIAA0408 KIAA1217 MAPK1 MAPK3 NCK1 NCKIPSD NOTCH3 PAK2 PAK5 RBMX SAFB2 SAXO1 SH2D4A SOCS7 SRCIN1 TBC1D22B TRIM23 TRIM27 TRIM41 VARS2 VPS37B VPS37C ZBED1 ZBTB25 ZBTB7B ZC4H2
Entrez ID		80725	10174
HPRD ID		11589	11535
Ensembl ID		ENSG00000277363	ENSG00000120896
Uniprot IDs		Q9C0H9	O60504
PDB IDs			2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?
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