RNF34 and APPBP2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		RNF34	APPBP2
Description		ring finger protein 34	amyloid beta precursor protein binding protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Endomembrane System Nuclear Body Nuclear Speck	Nucleus Cytoplasm Microtubule Microtubule Associated Complex Cytoplasmic Vesicle Membrane
	Molecular Function	P53 Binding Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Phosphatidylinositol Phosphate Binding	Microtubule Motor Activity Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Cold Protein K48-linked Ubiquitination Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Oxygen Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Intracellular Protein Transport Intracellular Transport
Pathways		Regulation of TP53 Degradation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Waist-hip ratio ( 28552196)
Interacting Genes		9 interacting genes: APP APPBP2 DNAJA3 NOD1 PHF7 TRIM23 UBE2D2 UBE2F UBE2H	81 interacting genes: - AHCY AIM2 AK3 ANKRD10 APP AR ARMCX5 C1orf50 C6orf226 CALM3 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CTC1 CYBA DCD DHRS2 DPEP1 EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GSTP1 H2AC15 HIPK4 HSPA4 KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MFSD3 MLLT3 MUL1 NFYA NPRL3 PCSK5 PI4KAP2 PPP1R8 PRKAA2 PRKACB PYROXD2 RASSF5 RNF128 RNF34 RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SNX5 ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 UBE2R2 UGGT2 WAS WDR24 WNT5B ZC3H10 ZCCHC12 ZNF747
Entrez ID		80196	10513
HPRD ID		10509	05616
Ensembl ID		ENSG00000170633	ENSG00000062725
Uniprot IDs		A0A087WTM5 Q969K3	A0A024QZ47 Q92624
PDB IDs
Enriched GO Terms of Interacting Partners?
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