DOCK5 and ELMO1

Number of citations of the paper that reports this interaction (PubMedID 26186194)
367

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		DOCK5	ELMO1
Description		dedicator of cytokinesis 5	engulfment and cell motility 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Cytoplasm Cytosol Plasma Membrane Membrane Guanyl-nucleotide Exchange Factor Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding
	Biological Process	Small GTPase Mediated Signal Transduction Positive Regulation Of Epithelial Cell Migration Cell Migration Positive Regulation Of GTPase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Vascular Smooth Muscle Contraction Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration	Phagocytosis, Engulfment Apoptotic Process Cell Migration Rac Protein Signal Transduction Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Regulation Of Defense Response To Virus By Virus
Pathways		Factors involved in megakaryocyte development and platelet production	Nef and signal transduction Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Glucose homeostasis traits ( 25524916) Length of menstrual cycle ( 30202859) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) QT interval ( 29213071)	Alzheimer's disease (cognitive decline) ( 23535033) Anticoagulant levels ( 22216198) Body fat mass ( 28552196) Breast size ( 22747683) Celiac disease ( 22057235 20190752 25920553) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Cerebrospinal fluid AB1-42 levels ( 28247064) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Height ( 31562340) Inflammatory skin disease ( 25574825) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Mean platelet volume ( 27863252) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of granulocytes ( 27863252) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Platelet distribution width ( 27863252) Primary biliary cirrhosis ( 22961000) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624) QT interval ( 20031603) Response to treatment for acute lymphoblastic leukemia ( 19176441) Rheumatoid arthritis ( 23143596) Sum eosinophil basophil counts ( 27863252) Trunk fat mass ( 28552196) Type 2 diabetes nephropathy ( 17653210)
Interacting Genes		2 interacting genes: ATXN1 ELMO1	11 interacting genes: ADGRB1 ADGRB3 APBB1 DOCK1 DOCK2 DOCK5 FGD1 HCK RHOG TRIM54 ZNF398
Entrez ID		80005	9844
HPRD ID		09925	12102
Ensembl ID		ENSG00000147459	ENSG00000155849
Uniprot IDs		B9A015 Q68DL4 Q9H7D0	A4D1X5 Q92556
PDB IDs			2RQR 2VSZ 3A98
Enriched GO Terms of Interacting Partners?
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