PTCD2 and TRIM32

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PTCD2	TRIM32
Description		pentatricopeptide repeat domain 2	tripartite motif containing 32
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Cell Nucleus Cytoplasm Cytosol Striated Muscle Myosin Thick Filament
	Molecular Function	RNA Binding	Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Myosin Binding Tat Protein Binding Translation Initiation Factor Binding Identical Protein Binding Ubiquitin Binding Protein Self-association Ubiquitin Protein Ligase Activity
	Biological Process	Kidney Development Liver Development MRNA Processing Mitochondrion Organization Multicellular Organism Development Muscle Fiber Development Regulation Of MRNA Processing Ventricular Cardiac Muscle Tissue Morphogenesis	Protein Polyubiquitination Tissue Homeostasis Ubiquitin-dependent Protein Catabolic Process Actin Ubiquitination Response To UV Protein Ubiquitination Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Response To Tumor Necrosis Factor Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Muscle Cell Cellular Homeostasis Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Striated Muscle Cell Differentiation Axon Development Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Interleukin-17-mediated Signaling Pathway Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Positive Regulation Of Cell Motility
Pathways			Regulation of innate immune responses to cytosolic DNA Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Bardet-Biedl syndrome (BBS)
GWAS		Asthma (childhood onset) ( 31036433) Glaucoma ( 31959993) Intraocular pressure ( 29617998 29785010 31959993 30054594) Pulse pressure ( 27841878)	Estimated glomerular filtration rate ( 31015462)
Interacting Genes		2 interacting genes: MID2 TRIM32	41 interacting genes: ABI2 ATXN1 CLIP4 GLIS2 HSPA4 IQCB1 IRAK1 KCTD9 MID2 MYCN NDRG2 PDE9A PIAS3 PIAS4 PTCD2 PTPN11 RABAC1 RNF208 RNF41 SCGB1A1 SDCBP STING1 SYT6 TOP1 TRIM23 TRIM27 TRIM5 TRIM72 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBQLN1 UBQLN4 VPS11 XIAP
Entrez ID		79810	22954
HPRD ID		15193	03797
Ensembl ID		ENSG00000049883	ENSG00000119401
Uniprot IDs		A0A024RAM6 B3KPU6 B7Z8R2 F6S289 Q8WV60	A0A024R843 Q13049
PDB IDs			2CT2 5FEY
Enriched GO Terms of Interacting Partners?
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