ZYG11B and ARPC2

		ZYG11B	ARPC2
Description		zyg-11 family member B, cell cycle regulator	actin related protein 2/3 complex subunit 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cul2-RING Ubiquitin Ligase Complex	Nucleus Endosome Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Lamellipodium Site Of Double-strand Break Muscle Cell Projection Membrane Neuron Projection Extracellular Exosome Glutamatergic Synapse
	Molecular Function		Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding
	Biological Process	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Positive Regulation Of Lamellipodium Assembly Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Ephrin Receptor Signaling Pathway Membrane Organization Actin Polymerization-dependent Cell Motility Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways			Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs			N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS			Inflammatory bowel disease ( 28067908 23128233) Mean platelet volume ( 27863252) Neutrophil count ( 29403010) Obesity-related traits ( 23251661) Platelet count ( 27863252) Platelet distribution width ( 27863252) White blood cell count ( 25096241 29403010)
Interacting Genes		13 interacting genes: ARPC2 ASPA BTBD2 BTF3L4 CFL2 CUL2 ELOB ELOC NDC1 OSBPL9 SH2D2A TLR6 UCK2	8 interacting genes: ACTR3 ARPC1B ARPC4 AURKA CORO1B MDN1 WAS ZYG11B
Entrez ID		79699	10109
HPRD ID		13356	10367
Ensembl ID		ENSG00000162378	ENSG00000163466
Uniprot IDs		A8DPD7 B4DK95 Q9C0D3	A0A024R408 O15144 Q53R19
PDB IDs
Enriched GO Terms of Interacting Partners?
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