MCPH1 and EMG1

Number of citations of the paper that reports this interaction (PubMedID 29150431)
3

Data Source:
BioGRID (two hybrid)

		MCPH1	EMG1
Description		microcephalin 1	EMG1 N1-specific pseudouridine methyltransferase
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GO Annotations	Cellular Component	Cell Nucleoplasm Cytoplasm Microtubule Organizing Center	Nucleus Nucleoplasm Nucleolus Cytoplasm Small-subunit Processome
	Molecular Function	Protein Binding Identical Protein Binding	RNA Binding Protein Binding RRNA Binding RRNA (pseudouridine) Methyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation Cerebral Cortex Development Regulation Of Kinase Activity Regulation Of Centrosome Cycle Regulation Of Inflammatory Response Bone Development Regulation Of Chromosome Condensation Protein Localization To Centrosome Mitotic Cell Cycle Arrest Neuronal Stem Cell Population Maintenance	Blastocyst Development RRNA Processing Nucleologenesis Ribosomal Small Subunit Biogenesis RRNA Base Methylation
Pathways		Condensation of Prophase Chromosomes	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases		Primary microcephaly (MCPH)	Bowen-Conradi syndrome (BCS)
GWAS		Alcoholic chronic pancreatitis ( 28754779) Birth weight ( 31043758) Carotid intima media thickness ( 30510157) Cytomegalovirus antibody response ( 21993531) Diastolic blood pressure ( 30224653) Epirubicin-induced leukopenia ( 21799462) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010) Metabolite levels ( 23823483) Post bronchodilator FEV1/FVC ratio ( 26634245) Venlafaxine response in generalised anxiety disorder (remitters vs non-remitters after 24 weeks) ( 28437668)
Interacting Genes		68 interacting genes: ABCC2 ACTG1 AKIP1 AKR7A2 ATM ATR B3GALT6 CCDC77 CCT5 CHEK1 COL1A1 COL27A1 COPB2 COPS3 CTSL DNAJA3 DNAJC19 EIF3F EIF4A2 EMG1 ENO1 FBLN1 FLNA GABARAPL2 HNRNPA2B1 HSPD1 KAT5 KDM1A LAMTOR5 LGALS3 MCM2 MCM5 MITD1 MRPL46 MT2A NCCRP1 NMI NR2F1 OBSL1 PHF11 PMVK POLD1 POLR2G PPA1 PPRC1 RACK1 RBM39 RSL24D1 RUVBL2 S100A16 SMARCB1 SMARCC2 SMOX SUPT6H TADA2A TAF1D THAP11 TPT1 TRAP1 TSEN54 UXT VIM WDR53 WDR61 WDR73 WDR75 WNT10B ZMIZ2	12 interacting genes: ANXA3 APP CTSE FAM74A4 HIVEP1 IL7R KHDRBS1 MCPH1 NAA80 PSMB7 PSME1 SLC25A38
Entrez ID		79648	10436
HPRD ID		06174	12803
Ensembl ID		ENSG00000147316	ENSG00000126749
Uniprot IDs		Q8NEM0	Q92979
PDB IDs		2WT8 3KTF 3PA6 3SHT 3SHV 3SZM 3T1N 3U3Z	5FAI
Enriched GO Terms of Interacting Partners?
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