SRD5A3 and NUDT15

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		SRD5A3	NUDT15
Description		steroid 5 alpha-reductase 3	nudix hydrolase 15
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Cytosol
	Molecular Function	3-oxo-5-alpha-steroid 4-dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor Cholestenone 5-alpha-reductase Activity Polyprenol Reductase Activity	Protein Binding 8-oxo-7,8-dihydroguanosine Triphosphate Pyrophosphatase Activity Nucleoside-diphosphatase Activity NADH Pyrophosphatase Activity 8-oxo-7,8-dihydrodeoxyguanosine Triphosphate Pyrophosphatase Activity Metal Ion Binding Nucleoside-triphosphate Diphosphatase Activity
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Androgen Biosynthetic Process Polyprenol Catabolic Process Dolichol Metabolic Process Dolichol Biosynthetic Process Oxidation-reduction Process	Mitotic Cell Cycle Response To Reactive Oxygen Species Purine Nucleotide Catabolic Process DGTP Catabolic Process Nucleobase-containing Small Molecule Catabolic Process DNA Protection Exogenous Drug Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Nucleoside Phosphate Catabolic Process
Pathways		Androgen biosynthesis Synthesis of Dolichyl-phosphate Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ	Phosphate bond hydrolysis by NUDT proteins
Drugs		Spironolactone
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Estimated glomerular filtration rate ( 31015462) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 27558924 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)
Interacting Genes		2 interacting genes: ADK NUDT15	1 interacting genes: SRD5A3
Entrez ID		79644	55270
HPRD ID		07825	14848
Ensembl ID		ENSG00000128039	ENSG00000136159
Uniprot IDs		Q9H8P0	Q9NV35
PDB IDs			5BON 5LPG
Enriched GO Terms of Interacting Partners?
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