LENG1 and CARD9

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		LENG1	CARD9
Description		leukocyte receptor cluster member 1	caspase recruitment domain family member 9
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component	Cytoplasm Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Molecular_function Protein Binding	Protein Binding Protein Homodimerization Activity CARD Domain Binding
	Biological Process	Biological_process	Stimulatory C-type Lectin Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Response To Fungus Response To Peptidoglycan Response To Muramyl Dipeptide Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Exogenous DsRNA Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Defense Response To Virus
Pathways			NOD1/2 Signaling Pathway CLEC7A (Dectin-1) signaling
Drugs
Diseases			Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS		Pre-treatment viral load in HIV-1 infection ( 31219150)	Acute insulin response (insulin secretion adjusted) ( 28490609) Ankylosing spondylitis ( 23749187 21743469) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 22936669 21102463) IgA nephropathy ( 25305756) Inflammatory bowel disease ( 28067908 23128233) Joint damage in rheumatoid arthritis ( 26498133) Large artery stroke ( 28265093) Monocyte chemoattractant protein-1 levels ( 23017229) Obesity-related traits ( 23251661) Pediatric autoimmune diseases ( 26301688) Ulcerative colitis ( 19915572 28067908 20228799 21297633)
Interacting Genes		36 interacting genes: APP BANP CALCOCO2 CARD9 CBY2 CCDC102B CCDC136 CCDC57 CDR2 CEP57L1 CEP70 FSD2 GOLGA2 KASH5 KIFC3 KLF10 KRT31 KRT40 LDOC1 MID2 MTUS2 NAB2 NAGK NECAB2 OSGEP PAK5 PDE4DIP PNMA1 ROPN1 STX11 TCF4 TFIP11 TMEM239 TRIM27 TRIM54 USHBP1	69 interacting genes: ABLIM1 AMOTL2 AXIN1 BCL10 BLZF1 C1orf94 C2CD6 CCDC85B CCHCR1 CDCA7L CEP57L1 CEP70 CSNK2A1 CWF19L2 DAXX DUSP13 DVL2 EIF4E2 FAM124B FAM161A FAM50B HMBOX1 IHO1 IQCE KCTD9 KIAA0408 KIF9 KRT19 KRT31 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-5 LENG1 LMO1 LZTS2 MEOX2 MFAP1 NECAB2 PAK5 PBX2 PHC2 PNMA5 PPP1R18 RTP5 SSX2IP STX11 SUMO1 TASOR2 TCEANC TCL1A TFIP11 TLE5 TNFAIP1 TRIM23 TRIM29 TRIM42 TRIM54 TRIM62 TSNAX USP15 VPS28 ZCCHC7 ZNF250 ZNF417 ZNF572 ZNF587 ZNF655 ZNF688
Entrez ID		79165	64170
HPRD ID		13985	06236
Ensembl ID		ENSG00000105617	ENSG00000187796
Uniprot IDs		Q96BZ8	A0A024R8F1 Q9H257
PDB IDs			6E25 6E26 6E27 6E28 6N2M 6N2P
Enriched GO Terms of Interacting Partners?
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