RAB7A and RAB4B

Number of citations of the paper that reports this interaction (PubMedID 10329441)
20

Data Source:
BioGRID (two hybrid)

		RAB7A	RAB4B
Description		RAB7A, member RAS oncogene family	RAB4B, member RAS oncogene family
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GO Annotations	Cellular Component	Autophagosome Membrane Cell Lysosome Lysosomal Membrane Late Endosome Golgi Apparatus Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Endomembrane System Secretory Granule Membrane Phagocytic Vesicle Membrane Retromer Complex Late Endosome Membrane Extrinsic Component Of Lysosome Membrane Melanosome Membrane Phagophore Assembly Site Membrane Phagocytic Vesicle Extracellular Exosome	Endosome Plasma Membrane Endomembrane System Secretory Granule Membrane Insulin-responsive Compartment Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Retromer Complex Binding	Molecular_function GTPase Activity Protein Binding GTP Binding
	Biological Process	Autophagosome Assembly Protein Targeting To Lysosome Intracellular Protein Transport Endocytosis Epidermal Growth Factor Catabolic Process Endosome To Lysosome Transport Protein Transport Lipid Catabolic Process Viral Release From Host Cell Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Protein To Membrane Docking Rab Protein Signal Transduction Retrograde Transport, Endosome To Golgi Neutrophil Degranulation Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Positive Regulation Of Viral Process Establishment Of Vesicle Localization Lipophagy Phagosome Maturation Phagosome Acidification Phagosome-lysosome Fusion Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Negative Regulation Of Intralumenal Vesicle Formation	Intracellular Protein Transport Regulation Of Endocytosis Rab Protein Signal Transduction Neutrophil Degranulation Glucose Import
Pathways		MHC class II antigen presentation Neutrophil degranulation TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Suppression of autophagy	Neutrophil degranulation RAB geranylgeranylation MET receptor recycling
Drugs		Guanosine-5'-Diphosphate
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Body fat mass ( 28552196) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)	Blood protein levels ( 28240269) Chronic obstructive pulmonary disease ( 22080838 28166215) Emphysema imaging phenotypes ( 26030696) Kawasaki disease ( 22081228) Smoking behaviour (cigarettes smoked per day) ( 30617275)
Interacting Genes		35 interacting genes: CHM COPG1 ENOPH1 FABP6 GP9 H1-10 KRTAP10-3 KRTAP10-9 PPP2R1A PPP2R1B PRKN RAB13 RAB17 RAB22A RAB4A RAB4B RAB6A RABAC1 RABGGTB RILP RNF115 RPN1 SLC2A4 SNX3 TMCC1 TP53 UCHL5 VPS11 VPS16 VPS18 VPS26A VPS29 VPS39 VPS41 ZHX2	3 interacting genes: EXOC5 RAB7A RABAC1
Entrez ID		7879	53916
HPRD ID		03805	11473
Ensembl ID		ENSG00000075785	ENSG00000167578
Uniprot IDs		A0A158RFU6 P51149	A0A024R0K8 P61018
PDB IDs		1T91 1YHN 3LAW 6IYB	2O52
Enriched GO Terms of Interacting Partners?
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