CXCR4 and ITCH

Number of citations of the paper that reports this interaction (PubMedID 19116316)
43

Data Source:
BioGRID (affinity chromatography technology, pull down, biochemical, affinity chromatography technology)

		CXCR4	ITCH
Description		C-X-C motif chemokine receptor 4	itchy E3 ubiquitin protein ligase
Image
GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Lysosome Early Endosome Late Endosome Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Cell Junction Cell Leading Edge Cytoplasmic Vesicle Protein-containing Complex Extracellular Exosome	Nucleoplasm Cytoplasm Early Endosome Cytosol Plasma Membrane Membrane Early Endosome Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Virus Receptor Activity Actin Binding G Protein-coupled Receptor Activity Protein Binding Drug Binding Coreceptor Activity C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding Ubiquitin Protein Ligase Binding Myosin Light Chain Binding C-X-C Motif Chemokine 12 Receptor Activity Identical Protein Binding Ubiquitin Binding	Ubiquitin-protein Transferase Activity Protein Binding Ribonucleoprotein Complex Binding Ubiquitin-like Protein Ligase Binding CXCR Chemokine Receptor Binding Ubiquitin Protein Ligase Activity Arrestin Family Protein Binding
	Biological Process	Activation Of MAPK Activity Response To Hypoxia Neuron Migration Epithelial Cell Development Dendritic Cell Chemotaxis Apoptotic Process Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Brain Development Neuron Recognition Response To Virus Response To Activity Fusion Of Virus Membrane With Host Plasma Membrane Calcium-mediated Signaling Neurogenesis Telencephalon Cell Migration Regulation Of Cell Adhesion Positive Regulation Of Vascular Wound Healing Cellular Response To Drug CXCL12-activated CXCR4 Signaling Pathway Regulation Of Programmed Cell Death Myelin Maintenance Response To Morphine Entry Into Host Endothelial Cell Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Viral Process Regulation Of Chemotaxis Positive Regulation Of Chemotaxis Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Regulation Of Calcium Ion Transport Cardiac Muscle Contraction Cell Chemotaxis Endothelial Tube Morphogenesis Cellular Response To Cytokine Stimulus Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Dendrite Extension Positive Regulation Of Mesenchymal Stem Cell Migration Response To Ultrasound Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway	Protein Polyubiquitination Regulation Of Cell Growth Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Inflammatory Response Notch Signaling Pathway Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Protein K29-linked Ubiquitination Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of JNK Cascade Viral Entry Into Host Cell Negative Regulation Of Defense Response To Virus Defense Response To Virus Protein Autoubiquitination Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Protein Deubiquitination Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Receptor Catabolic Process
Pathways		Binding and entry of HIV virion Signaling by ROBO receptors Chemokine receptors bind chemokines G alpha (i) signalling events	Downregulation of ERBB4 signaling NOD1/2 Signaling Pathway Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Degradation of GLI1 by the proteasome Hedgehog 'on' state RUNX1 regulates transcription of genes involved in differentiation of HSCs Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Framycetin AMD-070 Plerixafor
Diseases		Chemokine receptor defect, including the following disease: WHIM syndrome
GWAS		Albumin-globulin ratio ( 29403010) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arthritis (juvenile idiopathic) ( 27005825) Body mass index ( 26426971) Colorectal cancer ( 29228715) Estimated glomerular filtration rate ( 31152163) Lung function (low FEV1 vs high FEV1) ( 26423011) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244 19525953) Non-albumin protein levels ( 29403010) Smoking status (ever vs never smokers) ( 30643258) Telomere length ( 20421499)	Bipolar disorder ( 31043756) Colorectal cancer or advanced adenoma ( 30510241) Estimated glomerular filtration rate ( 31152163 31015462) Heel bone mineral density ( 28869591) Vitiligo ( 27723757)
Interacting Genes		34 interacting genes: ARRB2 ATP13A2 B2M CCR5 CD4 CTSG CXCL12 DPP4 DUXAP9 ELANE GNA13 GNAI1 GRK3 HSPA8 ITCH JAK1 JAK2 JAK3 MYBL2 MYH9 PTK2 PTPN11 PTPN6 PTPRC RNF113A SDC4 SOCS1 SOCS3 STAT1 STAT2 STAT3 STAT5B USP14 VAV1	103 interacting genes: ARHGEF7 ARID1A ARRB2 ARRDC3 ATN1 BECN1 BIN1 BRAF CBL CBLC CDC34 CEP250 CPSF6 CPSF7 CSNK2A1 CXCR4 CYLD DAZAP1 DTX1 DTX3L ERBB4 EWSR1 FYN GLIS3 GNAI2 HNRNPL HNRNPUL1 JUN JUNB KPNB1 LAPTM5 LITAF LRRK1 MAP2K4 MAPK8 MARVELD2 MLANA N4BP1 NDFIP1 NDFIP2 NEDD9 NFE2 NOTCH1 NUDT21 NUMB PABPC1 PACSIN1 POLR2A POLR2B POLR2C POLR2E POU5F1 PRKACA RASSF5 RIPK1 RNF11 RPAP2 RPAP3 SCNN1A SCNN1B SF1 SGK3 SH3GL1 SH3GL2 SMAD2 SMAD3 SMARCC1 SMARCC2 SMARCE1 SMN1 SNX9 SPART STAM2 SUFU TAB1 TP63 TP73 TRPC4 TRPV1 TRPV4 TXNIP UBAP2 UBAP2L UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2J2 UBE2K UBE2L3 UBE2M UBE2O UBE2Q1 UBE2Q2 UBE2R2 URI1 WBP2
Entrez ID		7852	83737
HPRD ID		01217	07565
Ensembl ID		ENSG00000121966	ENSG00000078747
Uniprot IDs		A0A0U3FJG0 A0A0U3GXA9 P61073	A0A590UJQ1 Q96J02
PDB IDs		2K03 2K04 2K05 2N55 3ODU 3OE0 3OE6 3OE8 3OE9 4RWS	2DMV 2KYK 2NQ3 2P4R 2YSF 3TUG 4ROF 5C7M 5CQ2 5DWS 5DZD 5SXP
Enriched GO Terms of Interacting Partners?
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