ZMYM2 and SREBF2

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		ZMYM2	SREBF2
Description		zinc finger MYM-type containing 2	sterol regulatory element binding transcription factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol PML Body	Golgi Membrane Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane SREBP-SCAP-Insig Complex Intracellular Membrane-bounded Organelle
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding	C-8 Sterol Isomerase Activity RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein C-terminus Binding Protein Dimerization Activity E-box Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Biological_process Regulation Of Cell Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Cholesterol Metabolic Process Cellular Response To Starvation Positive Regulation Of Cholesterol Storage SREBP Signaling Pathway Response To Lipid Cholesterol Homeostasis Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cholesterol Efflux Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease	Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS		Facial emotion recognition (happy faces) ( 28608620) Hand grip strength ( 29691431)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Birth weight ( 31043758 27680694) General cognitive ability ( 29844566) Schizophrenia ( 25056061 29483656)
Interacting Genes		21 interacting genes: CEBPE CREB1 CREBBP FUS HNRNPA2B1 HNRNPH3 PTBP1 RCOR1 SFPQ SKIL SMAD3 SMAD4 SNIP1 SREBF2 SUMO1 TSC22D2 UBE2A UBE2I UBTF ZBTB3 ZNF512B	50 interacting genes: ABLIM1 ABLIM2 ARHGEF1 ARRB1 ATF7IP ATXN1 AURKA CASP3 CASP8AP2 COPS5 CREB1 CREBBP EGR1 EP300 FHL3 GOLGB1 HNF4A HSPA5 INSIG1 INSIG2 ITGB4 KLF13 KPNB1 LINC00839 LZTR1 MAPK1 MAPK3 MRPS6 MTNR1B NAE1 NFYA NFYC OS9 PIAS1 PIAS2 PIAS3 PSMD4 RAB11B SCAP SLC4A4 SMAD3 SP1 SPTBN1 SREBF1 SUMO1 TTC1 UBE2I ZDHHC17 ZMYM2 ZYX
Entrez ID		7750	6721
HPRD ID		03745	02726
Ensembl ID		ENSG00000121741	ENSG00000198911
Uniprot IDs		A0A024RDS3 A8K126 Q9UBW7	A0A024R1Q0 Q12772
PDB IDs			1UKL
Enriched GO Terms of Interacting Partners?
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