VTN and LNX2

Number of citations of the paper that reports this interaction (PubMedID 21516116)
94

Data Source:
BioGRID (two hybrid)

		VTN	LNX2
Description		vitronectin	ligand of numb-protein X 2
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Golgi Lumen Intracellular Membrane-bounded Organelle Rough Endoplasmic Reticulum Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Alphav-beta3 Integrin-vitronectin Complex Blood Microparticle
	Molecular Function	Scavenger Receptor Activity Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Heparin Binding Polysaccharide Binding Identical Protein Binding Extracellular Matrix Binding	Protein Binding PDZ Domain Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Endocytosis Immune Response Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Endopeptidase Activity Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Negative Regulation Of Blood Coagulation Extracellular Matrix Organization Regulation Of Complement Activation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Binding Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Positive Regulation Of Receptor-mediated Endocytosis Oligodendrocyte Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Protein Polymerization Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Wound Healing Liver Regeneration
Pathways		Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions ECM proteoglycans ECM proteoglycans Regulation of Complement cascade
Drugs		Abciximab Zinc Copper
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 30072576 29875488 28240269) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Osteoprotegerin levels ( 25080503)	Body mass index ( 26426971 28892062) Large B-cell lymphoma ( 21471979) Mean platelet volume ( 27863252) Night sleep phenotypes ( 27126917) Platelet distribution width ( 27863252) Response to cytadine analogues (cytosine arabinoside) ( 24483146)
Interacting Genes		43 interacting genes: ADH5 ADTRP AMPH APP CBX1 CD247 CKS2 COPS5 CRADD CSNK2A1 EGF ETV7 FGF2 FGG GEM GLUD1 GOPC HGF IGF2 IGFBP5 ITGA8 ITGB3 ITGB6 ITGB8 KNG1 LACRT LNX2 PLAUR POMC PRDX4 PRKACA PRKCA PRKCB PRKCG PVR RHOXF1 RPL13A SERPINE1 SIX1 TGFB1 TGFB2 TNFRSF11B VEGFA	89 interacting genes: ATP5F1B C10orf88 CABP4 CBX4 CCT3 CDK2 CDK4 CDKN2C CRK CXADR DDA1 DRAP1 EAF2 FANCG FHL3 GADD45A GJD2 GLRX3 GRAP2 GRB2 IGSF5 IL16 INMT IP6K2 L3MBTL2 LGALS14 LNX1 LRRC8E MAP2K5 MAPK9 MCM7 MDGA1 MLX MRFAP1L1 MSRB3 MYLIP NAGK NMD3 NOTCH1 NTAQ1 NUDT14 NUMB OPTN PARVG PDZRN3 PDZRN4 PEG10 PHYKPL PIK3R1 PIK3R3 PKDREJ POLR1C PPIH PPIL1 PSMD5 PSMF1 PTCD3 RAB6B RBM17 RLIM RNF138 ROPN1 RPA2 SCLY SCNM1 SFN SH3GLB2 SHISA2 SHTN1 SMARCB1 SRSF11 TAB1 TBC1D7 TCL1A TIFA TRAF1 TRAF2 TUBB UBE2D2 UBE2H UBE2I UBE2T UBE2Z USP2 VTN YJU2 ZNF148 ZNF410 ZNF581
Entrez ID		7448	222484
HPRD ID		01902	10042
Ensembl ID		ENSG00000109072	ENSG00000139517
Uniprot IDs		D9ZGG2 P04004	Q8N448
PDB IDs		1OC0 1S4G 1SSU 2JQ8 3BT1 3BT2 4K24 6O5E	2VWR 5DIN 5E11 5E1Y 5E21 5E22
Enriched GO Terms of Interacting Partners?
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