EZR and ADRA1B

Number of citations of the paper that reports this interaction (PubMedID 16352594)
20

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		EZR	ADRA1B
Description		ezrin	adrenoceptor alpha 1B
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Ruffle Immunological Synapse Uropod Extracellular Space Cell Cytoplasm Endosome Cytosol Actin Filament Plasma Membrane Microvillus Brush Border Focal Adhesion Actin Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Filopodium T-tubule Cortical Cytoskeleton Microvillus Membrane Vesicle Ruffle Membrane Protein-containing Complex Ciliary Basal Body Cell Projection Cell Body Microspike Plasma Membrane Raft Apical Part Of Cell Perinuclear Region Of Cytoplasm Cell Tip Extracellular Exosome Invadopodium Cell Periphery Astrocyte Projection Schwann Cell Microvillus Cytoplasmic Side Of Apical Plasma Membrane	Cell Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Caveola Nuclear Membrane
	Molecular Function	RNA Binding Actin Binding Protein Binding Microtubule Binding Protein C-terminus Binding Protein Domain Specific Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Identical Protein Binding S100 Protein Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding Protein Kinase A Binding ATPase Binding Disordered Domain Specific Binding	Adrenergic Receptor Activity Alpha1-adrenergic Receptor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Intestinal D-glucose Absorption Sphingosine-1-phosphate Receptor Signaling Pathway Cytoskeletal Anchoring At Plasma Membrane Leukocyte Cell-cell Adhesion Axon Guidance Regulation Of Cell Shape Regulation Of Cell Size Positive Regulation Of Gene Expression Protein Kinase A Signaling Gland Morphogenesis Membrane To Membrane Docking Microvillus Assembly Astral Microtubule Organization Actin Cytoskeleton Reorganization Receptor Internalization Regulation Of Microvillus Length Regulation Of Actin Cytoskeleton Organization Cellular Protein-containing Complex Localization Positive Regulation Of Multicellular Organism Growth Cortical Microtubule Organization Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Phosphatidylinositol-mediated Signaling Positive Regulation Of Protein Secretion Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Establishment Of Centrosome Localization Establishment Of Endothelial Barrier Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Protein Localization To Plasma Membrane Protein Localization To Cell Cortex Negative Regulation Of Interleukin-2 Secretion Regulation Of NIK/NF-kappaB Signaling Regulation Of Organelle Assembly Terminal Web Assembly Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of P38MAPK Cascade Positive Regulation Of Early Endosome To Late Endosome Transport	Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Behavior Intracellular Signal Transduction Glucose Homeostasis Positive Regulation Of MAPK Cascade Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Regulation Of Cardiac Muscle Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Pathways		Netrin-1 signaling Recycling pathway of L1 Recycling pathway of L1	Adrenoceptors G alpha (q) signalling events G alpha (12/13) signalling events
Drugs			Amphetamine Midodrine Ziprasidone Cabergoline Dapiprazole Amitriptyline Olanzapine Alfuzosin Clozapine Norepinephrine Mirtazapine Phenylephrine Loxapine Promazine Prazosin Imipramine Chlorpromazine Chlorpromazine Nortriptyline Amoxapine Clonidine Doxazosin Labetalol Nicardipine Verapamil Epinephrine Thioridazine Phentolamine Ergotamine Tamsulosin Methoxamine Trimipramine Risperidone Modafinil Propiomazine Fenoldopam Quinidine Phenoxybenzamine Maprotiline Oxymetazoline Ergoloid mesylate Carvedilol Doxepin Nefazodone Desipramine Terazosin Pergolide Bromocriptine Quetiapine Aripiprazole Lisdexamfetamine Paliperidone Mephentermine Methotrimeprazine Dextroamphetamine Phendimetrazine Propericiazine Acepromazine Thioproperazine Dronedarone R450 Epicept NP-1 Sertindole Mianserin Silodosin Droxidopa Xylometazoline Perospirone Brexpiprazole Dosulepin Etoperidone Cirazoline Synephrine Tiapride
Diseases
GWAS		Bladder cancer (smoking interaction) ( 24662972) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Hair color ( 29662168)	Diastolic blood pressure ( 27841878) Plasma anti-thyroglobulin levels ( 29678681) Psoriatic arthritis ( 26626624) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		51 interacting genes: ACTB ACTC1 ADORA2B ADRA1B ARF6 ARHGDIB CD44 CDH1 CDK5 CFTR CLIC5 CTNNB1 DLG1 EGFR FAS FASLG GZMM ICAM1 ICAM2 ICAM3 IQGAP1 L1CAM LCK MDM2 MME MPP3 MSN NF2 PALLD PIK3R1 PRKAR2A PRKCA PTK2 PTPRC RDX ROCK1 S100P SCYL3 SDC2 SELL SELP SLC9A3R1 SLC9A3R2 SPN TBC1D10A TMEM8B TSC1 VCAM1 VPS11 WFDC1 WWOX	11 interacting genes: ADRA1A AP2M1 EZR FLNC GNA11 GNAQ NOS1 PPP1R9B PRKCA SAG STAT1
Entrez ID		7430	147
HPRD ID		00475	00080
Ensembl ID		ENSG00000092820	ENSG00000170214
Uniprot IDs		P15311	P35368
PDB IDs		1NI2 4RM8 4RM9 4RMA
Enriched GO Terms of Interacting Partners?
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