VCP and MFN2

Number of citations of the paper that reports this interaction (PubMedID 29676259)
29

Data Source:
BioGRID (enzymatic study)

		VCP	MFN2
Description		valosin containing protein	mitofusin 2
Image
GO Annotations	Cellular Component	Proteasome Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Cytoplasmic Stress Granule Protein-containing Complex VCP-NPL4-UFD1 AAA ATPase Complex Secretory Granule Lumen Azurophil Granule Lumen Site Of Double-strand Break Derlin-1 Retrotranslocation Complex Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Ficolin-1-rich Granule Lumen ATPase Complex VCP-NSFL1C Complex	Mitochondrion Mitochondrial Outer Membrane Cytosol Microtubule Cytoskeleton Integral Component Of Membrane Intrinsic Component Of Mitochondrial Outer Membrane
	Molecular Function	RNA Binding Protein Binding ATP Binding Lipid Binding ATPase Activity Protein Phosphatase Binding Protein Domain Specific Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Deubiquitinase Activator Activity K48-linked Polyubiquitin Modification-dependent Protein Binding MHC Class I Protein Binding Identical Protein Binding ADP Binding Ubiquitin-like Protein Ligase Binding BAT3 Complex Binding Ubiquitin-specific Protease Binding	GTPase Activity Protein Binding GTP Binding Ubiquitin Protein Ligase Binding
	Biological Process	DNA Repair Double-strand Break Repair Protein Folding NADH Metabolic Process ER To Golgi Vesicle-mediated Transport Autophagy Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Proteasomal Protein Catabolic Process Positive Regulation Of Mitochondrial Membrane Potential Macroautophagy Protein Ubiquitination Protein Deubiquitination Viral Genome Replication Translesion Synthesis Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Complex Assembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Cellular Response To Heat Stress Granule Disassembly ERAD Pathway Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neutrophil Degranulation Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process ATP Metabolic Process Regulation Of Synapse Organization Mitotic Spindle Disassembly Transmembrane Transport Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Aggresome Assembly Error-free Translesion Synthesis ER-associated Misfolded Protein Catabolic Process Flavin Adenine Dinucleotide Catabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Autophagosome Maturation Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Lys63-specific Deubiquitinase Activity Regulation Of Aerobic Respiration Cellular Response To Arsenite Ion Positive Regulation Of Oxidative Phosphorylation Positive Regulation Of Ubiquitin-specific Protease Activity Positive Regulation Of ATP Biosynthetic Process	Blastocyst Formation Protein Targeting To Mitochondrion Apoptotic Process Response To Unfolded Protein Mitochondrial Membrane Organization Cell Cycle Arrest Blood Coagulation Mitochondrial Fusion Macroautophagy Protein Localization To Phagophore Assembly Site Negative Regulation Of Ras Protein Signal Transduction Camera-type Eye Morphogenesis Negative Regulation Of Smooth Muscle Cell Proliferation Mitochondrion Localization Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Pathways		Translesion Synthesis by POLH HSF1 activation ABC-family proteins mediated transport N-glycan trimming in the ER and Calnexin/Calreticulin cycle Hedgehog ligand biogenesis Hh mutants that don't undergo autocatalytic processing are degraded by ERAD Defective CFTR causes cystic fibrosis Josephin domain DUBs Ovarian tumor domain proteases Neutrophil degranulation E3 ubiquitin ligases ubiquitinate target proteins Protein methylation Aggrephagy	Pink/Parkin Mediated Mitophagy Factors involved in megakaryocyte development and platelet production
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester Phenethyl Isothiocyanate
Diseases		Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Response to quetiapine in schizophrenia ( 29503163)	Inflammatory skin disease ( 25574825) Plasma homocysteine levels ( 30339177) Platelet count ( 22139419) Tuberculosis ( 29036319)
Interacting Genes		84 interacting genes: ABHD17C AMFR ANKRD13A AR ATG5 ATXN1 ATXN3 ATXN7 BRCA1 BRSK2 BUD23 CEP19 CLUAP1 CRMP1 CSTF1 DERL1 DGCR6 DTNB ELAVL1 EPSTI1 ESR1 FAF2 FAM104A GZMK HDAC6 HERPUD1 HTT INSIG1 INSIG2 JAK2 LNX1 LZIC MAPK8IP2 MFN2 NDRG1 NF1 NFKBIA NGLY1 NOD2 NSFL1C NTAQ1 NUB1 OTULIN PIK3R3 PLAA PPP1R11 PRKCD PSMA1 PSMA7 PSMC1 PTPN3 RNF115 RNF19A RNF8 RPL9 RPS6KA1 SELENOS SH2D2A SIGMAR1 SLC43A3 STUB1 STX5 SUMO4 SVIP TOM1L1 TOMM34 UBC UBE4A UBE4B UBOX5 UBXN10 UBXN11 UBXN2A UBXN2B UBXN4 UBXN6 UBXN7 UFD1 VAMP2 VCPIP1 VCPKMT WAC WRN YWHAZ	4 interacting genes: MARCHF5 PITRM1 PRKN VCP
Entrez ID		7415	9927
HPRD ID		03013	08495
Ensembl ID		ENSG00000165280	ENSG00000116688
Uniprot IDs		P55072 V9HW80	O95140
PDB IDs		3EBB 3HU1 3HU2 3HU3 3QC8 3QQ7 3QQ8 3QWZ 3TIW 4KDI 4KDL 4KLN 4KO8 4KOD 4P0A 5B6C 5C18 5C19 5C1A 5C1B 5DYG 5DYI 5EPP 5FTJ 5FTK 5FTL 5FTM 5FTN 5GLF 5IFS 5IFW 5KIW 5KIY 5X4L 6G2V 6G2W 6G2X 6G2Y 6G2Z 6G30 6HD0 6MCK	6JFK 6JFL 6JFM
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?