USP1 and DTX3

Number of citations of the paper that reports this interaction (PubMedID 23105109)
16

Data Source:
BioGRID (two hybrid)

		USP1	DTX3
Description		ubiquitin specific peptidase 1	deltex E3 ubiquitin ligase 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleoplasm Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity Thiol-dependent Ubiquitinyl Hydrolase Activity	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Skeletal System Development Regulation Of DNA Repair Ubiquitin-dependent Protein Catabolic Process Response To UV Protein Deubiquitination Monoubiquitinated Protein Deubiquitination Interstrand Cross-link Repair DNA Damage Response, Detection Of DNA Damage	Notch Signaling Pathway Protein Ubiquitination
Pathways		Recognition of DNA damage by PCNA-containing replication complex Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Crohn's disease ( 26192919 28067908) Lipid traits ( 24386095) Metabolic syndrome ( 31589552) Regular attendance at a gym or sports club ( 29970889) Serum metabolite levels (CMS) ( 31636271) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		12 interacting genes: DTX3 FANCD2 FANCI KLHDC2 KPNA1 PCNA PHF7 TRAF6 TRIM46 UBB UBC UBE2K	25 interacting genes: DTX1 DTX2 RNF141 RNF38 TRAF4 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2DNL UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2K UBE2L3 UBE2L6 UBE2V1 UBE2W UEVLD USP1 USP2 USP21 XIAP ZDHHC17
Entrez ID		7398	196403
HPRD ID		04593	16842
Ensembl ID		ENSG00000162607	ENSG00000178498
Uniprot IDs		O94782	A0A024RB96 Q8N9I9
PDB IDs		6DO5
Enriched GO Terms of Interacting Partners?
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