UBA1 and MGMT

Number of citations of the paper that reports this interaction (PubMedID 8573590)
54

Data Source:
HPRD (in vivo, in vitro)

		UBA1	MGMT
Description		ubiquitin like modifier activating enzyme 1	O-6-methylguanine-DNA methyltransferase
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GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Endosome Membrane Desmosome Rough Endoplasmic Reticulum Membrane Extracellular Exosome	Nucleus Nucleoplasm Membrane
	Molecular Function	RNA Binding Ubiquitin Activating Enzyme Activity Protein Binding ATP Binding	DNA Binding Methylated-DNA-[protein]-cysteine S-methyltransferase Activity Methyltransferase Activity DNA-methyltransferase Activity Metal Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Protein Ubiquitination Protein Modification By Small Protein Conjugation	DNA Ligation DNA Repair DNA Methylation DNA Dealkylation Involved In DNA Repair Negative Regulation Of Apoptotic Process Positive Regulation Of Double-strand Break Repair
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	MGMT-mediated DNA damage reversal
Drugs		Hexatantalum Dodecabromide Quercetin	L-Cysteine Zinc S-Methylcysteine Benzylcysteine Dinitrochlorobenzene
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS			Alzheimer's disease in APOE e4- carriers ( 25778476) Anorexia nervosa ( 31308545) Chronotype ( 30696823) Drug experimentation measurement ( 30718321) Gut microbiota (functional units) ( 27694959) Hand grip strength ( 29691431 29313844) Heel bone mineral density ( 30598549) Inflammatory skin disease ( 25574825) Intraocular pressure ( 29617998) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295) Lead levels ( 26025379) Metabolite levels ( 23823483) Metabolite levels (X-11787) ( 23934736) MGMT methylation in smokers ( 26183928) Modic changes ( 30808802) Response to temozolomide ( 23047291) Tea consumption ( 31046077) Waist-to-hip circumference ratio (ever vs never smoking interaction) ( 23192594)
Interacting Genes		48 interacting genes: ABCF1 BUB3 CDC34 CDK1 CHEK1 ECHS1 GAN GRB2 HGS HSPH1 MGMT MTNR1A PIAS3 SEMA3F SMAD5 TAF9 TMCC2 TSSC4 TTC19 UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2J2 UBE2K UBE2L1 UBE2L3 UBE2L6 UBE2N UBE2Q2 UBE2R2 UBE2S UBE2T UBE2U UBE2W UBE2Z UBTD2	9 interacting genes: CREBBP CSNK2A1 CSNK2A2 EP300 ESR1 PCNA PRKACA PRKCA UBA1
Entrez ID		7317	4255
HPRD ID		02440	01135
Ensembl ID		ENSG00000130985	ENSG00000170430
Uniprot IDs		A0A024R1A3 P22314	B4DEE8 P16455
PDB IDs		4P22 6DC6	1EH6 1EH7 1EH8 1QNT 1T38 1T39 1YFH
Enriched GO Terms of Interacting Partners?
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