C5AR1 and C5AR2

Number of citations of the paper that reports this interaction (PubMedID 17322907)
78

Data Source:
HPRD (in vitro, in vivo)

		C5AR1	C5AR2
Description		complement C5a receptor 1	complement component 5a receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Secretory Granule Membrane Intracellular Membrane-bounded Organelle Apical Part Of Cell	Cell Plasma Membrane Basal Plasma Membrane Integral Component Of Membrane Apical Part Of Cell
	Molecular Function	Complement Component C5a Binding Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity	Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Activation Of MAPK Activity Microglial Cell Activation Complement Receptor Mediated Signaling Pathway Apoptotic Process Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Sensory Perception Of Chemical Stimulus Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Macrophage Chemotaxis Cell Proliferation In Hindbrain Regulation Of Complement Activation Neutrophil Chemotaxis Animal Organ Regeneration Response To Peptidoglycan Response To Lipopolysaccharide Complement Component C5a Signaling Pathway MRNA Transcription By RNA Polymerase II Neutrophil Degranulation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Astrocyte Activation Positive Regulation Of Epithelial Cell Proliferation Defense Response To Gram-positive Bacterium Cognition Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Neutrophil Chemotaxis Amyloid-beta Clearance Presynapse Organization Regulation Of Tau-protein Kinase Activity	Complement Receptor Mediated Signaling Pathway Chemotaxis Inflammatory Response Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Complement Activation Negative Regulation Of Tumor Necrosis Factor Production Complement Component C5a Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neutrophil Chemotaxis Negative Regulation Of Interleukin-6 Secretion Regulation Of Interleukin-8 Secretion
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation Regulation of Complement cascade	Peptide ligand-binding receptors Regulation of Complement cascade
Drugs
Diseases
GWAS		Chronic periodontitis ( 25008200)
Interacting Genes		7 interacting genes: ARRB1 ARRB2 C5 C5AR2 GNAI2 RPS19 WAS	3 interacting genes: C3 C4A C5AR1
Entrez ID		728	27202
HPRD ID		00224	17072
Ensembl ID		ENSG00000197405	ENSG00000134830
Uniprot IDs		P21730	Q9P296
PDB IDs		5O9H 6C1Q 6C1R
Enriched GO Terms of Interacting Partners?
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