TRPC6 and ORAI1

Number of citations of the paper that reports this interaction (PubMedID 17360584)
114

Data Source:
HPRD (in vivo, in vitro)

		TRPC6	ORAI1
Description		transient receptor potential cation channel subfamily C member 6	ORAI calcium release-activated calcium modulator 1
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GO Annotations	Cellular Component	Cell Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Cation Channel Complex Slit Diaphragm	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Basolateral Plasma Membrane Protein-containing Complex Plasma Membrane Raft Membrane Raft
	Molecular Function	Actin Binding Cation Channel Activity Protein Binding Store-operated Calcium Channel Activity Clathrin Binding Protein Homodimerization Activity Actinin Binding ATPase Binding Inositol 1,4,5 Trisphosphate Binding	Protein Binding Calmodulin Binding Store-operated Calcium Channel Activity Identical Protein Binding
	Biological Process	Cation Transport Manganese Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Single Fertilization Aging Positive Regulation Of Peptidyl-threonine Phosphorylation Platelet Activation Neuron Differentiation Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Neuron Differentiation Negative Regulation Of Dendrite Morphogenesis Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Transport Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Hypoxia	Store-operated Calcium Entry Adaptive Immune Response Positive Regulation Of Adenylate Cyclase Activity Regulation Of Calcium Ion Transport Positive Regulation Of Calcium Ion Transport Mammary Gland Epithelium Development Calcium Ion Import Calcium Ion Transmembrane Transport
Pathways		Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling	Elevation of cytosolic Ca2+ levels Ion homeostasis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429) General risk tolerance (MTAG) ( 30643258) Lung adenocarcinoma ( 28604730) Menarche (age at onset) ( 25231870) Severity of nausea and vomiting of pregnancy ( 29563502)	Experiencing mood swings ( 29500382) Major depressive disorder ( 27777418)
Interacting Genes		9 interacting genes: FYN ITPR3 MX1 ORAI1 RNF24 SRC TRPC3 TRPC7 TRPM2	2 interacting genes: TRPC3 TRPC6
Entrez ID		7225	84876
HPRD ID		04710	08599
Ensembl ID		ENSG00000137672
Uniprot IDs		Q9Y210	A0A024RBT3 Q96D31
PDB IDs		5YX9	2MAK 4EHQ
Enriched GO Terms of Interacting Partners?
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