TRIP6 and TLR2

Number of citations of the paper that reports this interaction (PubMedID 15657077)
17

Data Source:
HPRD (in vivo)

		TRIP6	TLR2
Description		thyroid hormone receptor interactor 6	toll like receptor 2
Image
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion	Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Secretory Granule Membrane Phagocytic Vesicle Membrane Intrinsic Component Of Plasma Membrane Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Cell Projection Cell Body Membrane Raft
	Molecular Function	RNA Binding Interleukin-1 Receptor Binding Protein Binding Kinase Binding Metal Ion Binding Thyroid Hormone Receptor Binding	Lipopolysaccharide Binding Amyloid-beta Binding Lipopolysaccharide Receptor Activity Protein Binding Toll-like Receptor Binding Signaling Receptor Activity Pattern Recognition Receptor Activity Triacyl Lipopeptide Binding Identical Protein Binding Peptidoglycan Binding Protein-containing Complex Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	Signal Transduction Positive Regulation Of Cell Migration Chordate Embryonic Development Focal Adhesion Assembly Positive Regulation Of NIK/NF-kappaB Signaling	Response To Hypoxia Microglial Cell Activation Cell Activation Toll-like Receptor Signaling Pathway Cytokine Secretion Involved In Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Leukotriene Metabolic Process Apoptotic Process Inflammatory Response Immune Response Signal Transduction I-kappaB Phosphorylation Learning Negative Regulation Of Cell Proliferation Response To Toxic Substance Positive Regulation Of Gene Expression Microglia Development Positive Regulation Of Wnt Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Central Nervous System Myelin Formation Response To Progesterone Interleukin-10 Production Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Response To Insulin Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Detection Of Triacyl Bacterial Lipopeptide Detection Of Diacyl Bacterial Lipopeptide Neutrophil Degranulation Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Nitric Oxide Metabolic Process Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Negative Regulation Of Synapse Assembly Response To Fatty Acid Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoteichoic Acid Cellular Response To Interferon-gamma Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Interleukin-6 Secretion
Pathways			ER-Phagosome pathway Beta defensins MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor TLR6:TLR2 Cascade MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Neutrophil degranulation Modulation by Mtb of host immune system
Drugs			Lyme disease vaccine (recombinant OspA) S-(Dimethylarsenic)Cysteine Golotimod Tuberculin Purified Protein Derivative
Diseases
GWAS		Bipolar disorder ( 31043756) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Nonunion in individuals with fractures ( 30680360) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)	Body fat mass ( 28552196)
Interacting Genes		112 interacting genes: ABI2 ADAMTSL4 AQP1 ARNT2 ATN1 ATP23 ATP5PO ATXN1 AXIN1 BCAR1 BYSL CATSPER1 CBLC CCL5 CEP57L1 CNTF CREB5 CRYBA4 CTAG2 DHX37 DMRT3 DTX2 EFHC1 EXOC3-AS1 FAM124B FASLG FHL3 FRS3 GAD1 GATA1 GDPD5 GFI1B GNAI2 GSE1 HLA-DPB1 HOXA1 HOXA9 HOXB9 HYKK IL16 ILF3 INCA1 IQCN KIF1A KIR2DL4 KLK15 KRTAP26-1 LMO2 LPAR2 MAPKBP1 MEMO1 METTL17 MSRB3 MVP NCK2 NEDD9 NEU4 NOL4L-DT NUP210 ODF1 OIP5 OTUB2 PDGFRB PDLIM4 PIN1 POM121 POM121L4P PPP1R16A PRKAA1 PRKAA2 PTK2 PTPN13 PXN RAD23A RERE RFX3 RHOA RHOQ RNF213 RNF214 SAXO1 SCRIB SIK3 SLC15A3 SLC25A6 SMAD1 SON SRC STAC STK16 SVIL SYNGAP1 TAB1 TCAF1 TEKT4 TENT5C THRB TLR2 TMSB4X TPM3 TPM4 TRAF3IP2 TRAPPC2L TRIM29 TTLL10 TXN2 TXNDC5 VCL WT1-AS YPEL3 ZBP1 ZNF688	19 interacting genes: CD14 EGFR HMGB1 HRAS HSP90B1 IRAK1 LY96 MAPK8IP3 MYD88 PIK3R1 RAC1 RIPK2 TICAM1 TIRAP TLR1 TLR10 TLR6 TOLLIP TRIP6
Entrez ID		7205	7097
HPRD ID		04242	04323
Ensembl ID		ENSG00000087077	ENSG00000137462
Uniprot IDs		Q15654	A0A0S2Z4S4 B3KWR9 O60603
PDB IDs		1X61 2DLO	1FYW 1FYX 1O77 2Z7X 2Z80 6NIG
Enriched GO Terms of Interacting Partners?
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