TRAF2 and TNF

Number of citations of the paper that reports this interaction (PubMedID 12887920)
653

Data Source:
HPRD (in vivo)

		TRAF2	TNF
Description		TNF receptor associated factor 2	tumor necrosis factor
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Tumor Necrosis Factor Receptor Superfamily Complex Nucleoplasm Cytosol Cell Cortex Cytoplasmic Side Of Plasma Membrane Vesicle Membrane CD40 Receptor Complex Membrane Raft TRAF2-GSTP1 Complex Plasma Membrane Receptor Complex IRE1-TRAF2-ASK1 Complex	Phagocytic Cup Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Raft Recycling Endosome
	Molecular Function	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Protein Binding, Bridging Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding Tumor Necrosis Factor Binding Protein-containing Complex Binding Sphingolipid Binding	Protease Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Identical Protein Binding Transcription Regulatory Region DNA Binding
	Biological Process	Positive Regulation Of T Cell Cytokine Production Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Activation Of NF-kappaB-inducing Kinase Activity Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Deubiquitination Protein Catabolic Process Positive Regulation Of Interleukin-2 Production Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Cellular Protein-containing Complex Assembly Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Complex Assembly Positive Regulation Of JUN Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Immunoglobulin Secretion Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Protein-containing Complex Assembly Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K63-linked Ubiquitination Death-inducing Signaling Complex Assembly Cellular Response To Nitric Oxide Programmed Necrotic Cell Death Negative Regulation Of Neuron Death Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of I-kappaB Phosphorylation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Activation Of MAPKKK Activity Activation Of MAPK Activity Microglial Cell Activation Positive Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Negative Regulation Of Endothelial Cell Proliferation Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Glucose Metabolic Process Regulation Of Transcription By RNA Polymerase II Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Humoral Immune Response I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Virus Response To Salt Stress Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Alkaline Phosphatase Activity Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Lipid Storage Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cytokine-mediated Signaling Pathway Extracellular Matrix Organization Osteoclast Differentiation Sequestering Of Triglyceride Cortical Actin Cytoskeleton Organization Positive Regulation Of Protein Complex Assembly Positive Regulation Of Fever Generation Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Receptor Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Myosin-light-chain-phosphatase Activity Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Protein Complex Disassembly Positive Regulation Of Protein Complex Disassembly Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Viral Genome Replication Positive Regulation Of Chemokine Biosynthetic Process Positive Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Adhesion Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Translational Initiation By Iron Negative Regulation Of Glucose Import Positive Regulation Of JAK-STAT Cascade Astrocyte Activation Embryonic Digestive Tract Development Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Cytokine Secretion Positive Regulation Of Inflammatory Response Positive Regulation Of Fractalkine Biosynthetic Process Positive Regulation Of Phagocytosis Negative Regulation Of Neurogenesis Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission Regulation Of Synapse Organization Defense Response To Gram-positive Bacterium Cognition Leukocyte Tethering Or Rolling Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Immunoglobulin Secretion Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Protein Transport Response To Glucocorticoid Positive Regulation Of Hair Follicle Development Positive Regulation Of Protein Kinase B Signaling Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Calcidiol 1-monooxygenase Activity Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Amino Acid Stimulus Cellular Response To Nicotine Cellular Response To Organic Cyclic Compound Death-inducing Signaling Complex Assembly Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Podosome Assembly Endothelial Cell Apoptotic Process Protein Localization To Plasma Membrane Positive Regulation Of Chemokine Secretion Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Positive Regulation Of Neuroinflammatory Response Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Superoxide Dismutase Activity Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Positive Regulation Of Protein Localization To Cell Surface Positive Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Blood Microparticle Formation Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Interleukin-6 Secretion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases Dimerization of procaspase-8 TNF signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation	Transcriptional regulation of white adipocyte differentiation TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR1-mediated ceramide production TNFR2 non-canonical NF-kB pathway Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling TNF signaling
Drugs			Etanercept Adalimumab Infliximab Chloroquine Epinephrine Pseudoephedrine Thalidomide Glucosamine Clenbuterol Pranlukast Amrinone Isopropyl Alcohol Afelimomab YSIL6 SD118 PN0621 OMS-103HP Talmapimod VX-702 Apremilast CRx-139 CYT007-TNFQb Andrographolide Ethyl pyruvate AME-527 Dexanabinol Golimumab Certolizumab pegol Pomalidomide Binimetinib Dilmapimod
Diseases			Graft-versus-host disease Asthma Allograft rejection Systemic lupus erythematosus
GWAS			AIDS progression ( 19115949) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Cervical cancer ( 28806749) Crohn's disease ( 21102463) Inflammatory bowel disease ( 28067908) Neonatal lupus ( 20662065) Psychosis (atypical) ( 24132900) Pulse pressure ( 30578418) Ulcerative colitis ( 28067908)
Interacting Genes		258 interacting genes: AASDHPPT ABLIM1 ACTN3 AFF4 AIMP2 ALPL AMOTL2 ANKRD11 ANKRD36BP1 APEX2 APPL1 AQP1 ARNT2 ARSJ ASCC1 ATXN1 ATXN7 AXIN1 BAHD1 BANP BCL10 BECN1 BEX2 BEX3 BIRC2 BIRC3 CALCOCO2 CASP8 CASP8AP2 CATSPER1 CAV1 CBX8 CCDC130 CCDC198 CCDC33 CCHCR1 CCNJL CD27 CD40 CDC20B CDC42 CDCA3 CDK9 CDKN1B CEP57L1 CFAP57 CFLAR CHMP2B CHUK CREB5 CRY1 CYB5R2 CYLD DGCR6 DLGAP5 DTNB DVL2 EDAR EDARADD EFEMP1 EFHC1 EGFR EIF4G1 ELOA2 ENKD1 EP300 ERN1 ETV6 EWSR1 EXOC3-AS1 FADD FAM107A FAM120B FAM90A1 FATE1 FBF1 FBXO28 FDXACB1 FLNA FNDC11 FNDC3B FXR2 GABPB1 GCKR GORASP2 GPKOW GSG1 GSTP1 HENMT1 HINFP HIVEP3 HOXA1 IKBKB IL15RA IPO11 IQUB IRF4 ITPK1 JUN KANSL1 KIAA0408 KIF26B KIFC3 KLF3 LINC02875 LNX1 LNX2 LRRK2 LTBR LZTS2 MALT1 MAP3K14 MAP3K5 MAP3K8 MAP4K2 MAP4K5 MAPK9 MAPRE1 MAST2 MORN3 MPP3 MVP NATD1 NCAPH2 NEBL NECAP2 NFIL3 NGFR NIF3L1 NMUR2 NR2C2 NR4A1 NRF1 NRIP1 NUDT16L1 NUDT18 PACS2 PCGF5 PDLIM7 PEG3 PGBD1 PIN1 PKN1 PPL PPP1R18 PRKAB2 PRKRIP1 PSME3IP1 PSMF1 QARS1 RAD23A RALBP1 RAPGEF4 RASSF5 RBM41 RCOR3 RFX3 RGS14 RIBC2 RIPK1 RIPK2 RIPK3 RIPPLY1 RNF146 RRAS2 SETD5 SH2D4A SIAH2 SMG9 SMURF2 SNRNP25 SOX30 SOX9 SPATA2 SPG21 SPHK1 SPRY2 SUMO1P1 SYT17 TAB1 TAB2 TAB3 TANK TAOK3 TBK1 TCEA2 TCEANC TDP2 TEKT3 THAP7 THOP1 TICAM1 TIFA TLE5 TNF TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF25 TNFRSF4 TNFRSF8 TNFRSF9 TNFSF4 TNFSF9 TNIK TRADD TRAF1 TRAF3 TRAF3IP2 TRAF5 TRAF6 TRAIP TRIM31 TRIM37 TRIM42 TROAP TRPC4AP TRPT1 TSHZ3 TSSC4 UBC UBE2D1 UBE2D2 UBE2N UBE2V1 UBE2V2 UBQLN4 UBXN11 USF1 USP2 USP4 USP53 USP7 VWA2 YES1 ZBTB16 ZBTB25 ZBTB43 ZBTB49 ZC2HC1C ZFAND6 ZMAT2 ZNF205 ZNF410 ZNF488 ZNF544 ZNF646 ZNF655 ZNF662 ZNF688 ZSCAN32	21 interacting genes: ADAM17 ADAM9 BGN CSF1 DCN FYN IFNG LMNA LYN MMP17 NFKBIA PDIK1L POU2F1 PRTN3 RC3H1 RIPK1 SEC61A1 TNFRSF1A TNFRSF1B TRAF2 YWHAQ
Entrez ID		7186	7124
HPRD ID		03538	01855
Ensembl ID		ENSG00000127191	ENSG00000232810
Uniprot IDs		A0A024R8H5 Q12933	P01375 Q5STB3
PDB IDs		1CA4 1CA9 1CZY 1CZZ 1D00 1D01 1D0A 1D0J 1F3V 1QSC 3KNV 3M06 3M0A 3M0D	1A8M 1TNF 2AZ5 2E7A 2TUN 2ZJC 2ZPX 3ALQ 3IT8 3L9J 3WD5 4G3Y 4TSV 4TWT 4Y6O 5M2I 5M2J 5M2M 5MU8 5TSW 5UUI 5WUX 5YOY 6RMJ
Enriched GO Terms of Interacting Partners?
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