C1S and SERPING1

Number of citations of the paper that reports this interaction (PubMedID 3756141)
53

Data Source:
HPRD (in vivo, in vitro)

		C1S	SERPING1
Description		complement C1s	serpin family G member 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Blood Microparticle	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Identical Protein Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Proteolysis Complement Activation Complement Activation, Classical Pathway Regulation Of Complement Activation Innate Immune Response	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Complement Activation, Classical Pathway Aging Blood Coagulation, Intrinsic Pathway Blood Circulation Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Fibrinolysis Innate Immune Response
Pathways		Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Regulation of Complement cascade
Drugs		Cetuximab Etanercept Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab tiuxetan Zinc 2-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Ethanesulfonic Acid Human C1-esterase inhibitor Copper Conestat alfa	C1-INH Copper
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency	Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency Hereditary angioedema
GWAS		Activated partial thromboplastin time ( 29403010) Blood protein levels ( 29875488 28240269) Coronary artery disease ( 29212778) Lung cancer in never smokers ( 28604730) Red blood cell fatty acid levels ( 25500335) Red cell distribution width ( 27863252)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576 29875488 28240269) Neuroticism ( 29255261) Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656)
Interacting Genes		5 interacting genes: C1QA C1R IMPDH2 SERPING1 VKORC1	15 interacting genes: BAG6 C1R C1S ELANE ENO1 F2 MASP1 MASP2 NR4A1 PLAT PLG SELE SELP SLC30A2 SRPK2
Entrez ID		716	710
HPRD ID		00397	06033
Ensembl ID		ENSG00000182326	ENSG00000149131
Uniprot IDs		F8WCZ6 P09871	E9KL26 P05155
PDB IDs		1ELV 1NZI 4J1Y 4LMF 4LOR 4LOS 4LOT 6F1C 6F1H	1M6Q 2OAY 5DU3 5DUQ
Enriched GO Terms of Interacting Partners?
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