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TLR1 and TLR9
Number of citations of the paper that reports this interaction (PubMedID
12600829
)
13
Data Source:
HPRD
(in vitro)
TLR1
TLR9
Description
toll like receptor 1
toll like receptor 9
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Membrane
Phagocytic Vesicle Membrane
Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex
Membrane Raft
Golgi Membrane
Extracellular Region
Cytoplasm
Lysosome
Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Plasma Membrane
Endosome Membrane
Integral Component Of Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Early Phagosome
Endolysosome
Endolysosome Membrane
Molecular Function
Transmembrane Signaling Receptor Activity
Protein Binding
Toll-like Receptor 2 Binding
Signaling Receptor Activity
Identical Protein Binding
NAD(P)+ Nucleosidase Activity
NAD+ Nucleotidase, Cyclic ADP-ribose Generating
Lipopeptide Binding
Transmembrane Signaling Receptor Activity
Interleukin-1 Receptor Binding
SiRNA Binding
Pattern Recognition Receptor Activity
Protein Homodimerization Activity
Unmethylated CpG Binding
Biological Process
Cell Activation
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Inflammatory Response
Immune Response
Signal Transduction
Toll-like Receptor 1 Signaling Pathway
Positive Regulation Of Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Macrophage Activation
Detection Of Triacyl Bacterial Lipopeptide
Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process
Innate Immune Response
Positive Regulation Of Interleukin-6 Biosynthetic Process
Cellular Response To Bacterial Lipopeptide
Cellular Response To Triacyl Bacterial Lipopeptide
Positive Regulation Of Interleukin-8 Secretion
Toll-like Receptor Signaling Pathway
Response To Molecule Of Bacterial Origin
Positive Regulation Of Immunoglobulin Production
MyD88-dependent Toll-like Receptor Signaling Pathway
Inflammatory Response
Immune Response
I-kappaB Kinase/NF-kappaB Signaling
I-kappaB Phosphorylation
Positive Regulation Of Gene Expression
Maintenance Of Gastrointestinal Epithelium
Positive Regulation Of B Cell Proliferation
Negative Regulation Of NF-kappaB Transcription Factor Activity
Tumor Necrosis Factor Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Interleukin-8 Production
Positive Regulation Of Chemokine Production
Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-18 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Toll-like Receptor Signaling Pathway
Positive Regulation Of Toll-like Receptor Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Regulation Of Toll-like Receptor 9 Signaling Pathway
Defense Response To Bacterium
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAPK Cascade
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Interferon-gamma Biosynthetic Process
Innate Immune Response
Positive Regulation Of Interferon-alpha Biosynthetic Process
Positive Regulation Of Interferon-beta Biosynthetic Process
Positive Regulation Of Interleukin-8 Biosynthetic Process
Regulation Of B Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Regulation Of Cytokine Secretion
Positive Regulation Of Inflammatory Response
Defense Response To Gram-negative Bacterium
Positive Regulation Of B Cell Activation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Defense Response To Virus
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Positive Regulation Of NIK/NF-kappaB Signaling
Negative Regulation Of Calcium-transporting ATPase Activity
Pathways
ER-Phagosome pathway
Beta defensins
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Toll Like Receptor TLR1:TLR2 Cascade
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand
PI3K Cascade
Trafficking and processing of endosomal TLR
Toll Like Receptor 9 (TLR9) Cascade
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome
Drugs
Chloroquine
Hydroxychloroquine
ISS-1018
Golotimod
CPG 10101
Diseases
GWAS
Alcohol consumption (
23743675
)
Allergic disease (asthma, hay fever or eczema) (
29083406
29785011
)
Allergic rhinitis (
30013184
31361310
)
Allergic sensitization (
30013184
23817571
)
Allergy (
27182965
)
Asthma (
31361310
30929738
27182965
31619474
)
Asthma (age of onset) (
31036433
)
Asthma (childhood onset) (
31036433
30929738
)
Asthma and hay fever (
24388013
)
Asthma onset (childhood vs adult) (
30929738
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Composite immunoglobulin trait (IgG/IgM) (
28628107
)
Coronary artery calcified atherosclerotic plaque score in type 2 diabetes (
29221444
)
Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) (
27670767
)
Helicobacter pylori serologic status (
23652523
)
Self-reported allergy (
23817569
)
Systemic sclerosis (anti-topoisomerase-positive) (
29293537
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
21926972
)
Feeling nervous (
29500382
)
General cognitive ability (
29844566
)
Parkinson's disease (
28892059
)
Schizophrenia (
23974872
)
Interacting Genes
9 interacting genes:
DHX36
HSP90B1
HSPD1
TLR10
TLR2
TLR4
TLR5
TLR9
TRAP1
6 interacting genes:
BTK
HRAS
MAPK8IP3
RNF216
SIGIRR
TLR1
Entrez ID
7096
54106
HPRD ID
03119
05685
Ensembl ID
ENSG00000174125
ENSG00000239732
Uniprot IDs
Q15399
Q9NR96
PDB IDs
1FYV
2Z7X
6NIH
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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