C1QBP and NFKBIE

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		C1QBP	NFKBIE
Description		complement C1q binding protein	NFKB inhibitor epsilon
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Cell Surface Membrane Presynaptic Active Zone Glutamatergic Synapse GABA-ergic Synapse	Fibrillar Center Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Complement Component C1q Binding Transcription Corepressor Activity MRNA Binding Protein Kinase C Binding Protein Binding Hyaluronic Acid Binding Transcription Factor Binding Translation Activator Activity Kininogen Binding Adrenergic Receptor Binding Mitochondrial Ribosome Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MRNA Processing Apoptotic Process Immune Response Complement Activation, Classical Pathway Blood Coagulation, Intrinsic Pathway RNA Splicing Phosphatidylinositol 3-kinase Signaling Viral Process Regulation Of Complement Activation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of MDA-5 Signaling Pathway Negative Regulation Of RIG-I Signaling Pathway Mature Ribosome Assembly Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Cell Adhesion Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Defense Response To Virus Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Translation Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Trophoblast Cell Migration Positive Regulation Of Dendritic Cell Chemotaxis	D-serine Transport Cytoplasmic Sequestering Of Transcription Factor
Pathways		Apoptotic factor-mediated response Intrinsic Pathway of Fibrin Clot Formation Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function	Activation of NF-kappaB in B cells
Drugs		Hyaluronic acid Copper
Diseases			Hodgkin lymphoma
GWAS		Rheumatoid arthritis ( 30423114 24390342)	Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Rheumatoid arthritis ( 30423114 22446963 23028356 24390342)
Interacting Genes		26 interacting genes: C1QA CEBPA COIL EXOSC6 GAB1 GABRB1 HABP4 HMGB1 HMGB2 HNRNPD HRK MAPK1 MAPK3 MMP14 NFKBIE NFYB PRKCA PRKCD PRKCZ PRKD1 PRRC2A SRSF1 SRSF9 TOP3B YWHAB YWHAG	15 interacting genes: ANKHD1 C1QBP CUL1 HDAC4 HDAC5 IL1A JUP KBTBD7 NCOR2 NFKB1 NFKB2 PPP6C REL RELA SKP1
Entrez ID		708	4794
HPRD ID		03168	05181
Ensembl ID		ENSG00000108561	ENSG00000146232
Uniprot IDs		Q07021	A0A024RD24 O00221 Q7LC14 Q96F31
PDB IDs		1P32 3RPX
Enriched GO Terms of Interacting Partners?
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