TGM2 and ADAR

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		TGM2	ADAR
Description		transglutaminase 2	adenosine deaminase RNA specific
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GO Annotations	Cellular Component	Cell Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Focal Adhesion Intrinsic Component Of Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane Supraspliceosomal Complex
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding GTP Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding	DNA Binding RNA Binding Double-stranded RNA Binding Double-stranded RNA Adenosine Deaminase Activity Protein Binding TRNA-specific Adenosine Deaminase Activity Metal Ion Binding
	Biological Process	Blood Vessel Remodeling Peptide Cross-linking Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation	Osteoblast Differentiation Hematopoietic Progenitor Cell Differentiation Somatic Diversification Of Immune Receptors Via Somatic Mutation Adenosine To Inosine Editing RNA Processing MRNA Processing Response To Virus Base Conversion Or Substitution Editing Erythrocyte Differentiation Pre-miRNA Processing MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Response To Interferon-alpha Negative Regulation Of Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Definitive Hemopoiesis Type I Interferon Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Hematopoietic Stem Cell Homeostasis Cellular Response To Virus Negative Regulation Of RNA Interference
Pathways			C6 deamination of adenosine Formation of editosomes by ADAR proteins Interferon alpha/beta signaling
Drugs		Guanosine-5'-Diphosphate
Diseases			Dyschromatosis symmetrica hereditaria
GWAS			C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Lung cancer ( 28604730) Prostate cancer ( 23535732) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		59 interacting genes: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ARNT ATF4 BNIP3 C3 CASP3 CBL CERT1 CSNK2A2 EIF5A FN1 FNTA GCGR GRN GSTP1 H2BC21 H2BC8 HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGB1 ITGB3 KPNA3 KPNA4 LACRT LTBP1 MAP3K12 PAK1 PINK1 PLCD1 PPHLN1 PXN RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SPARC TAB2 TMEM176A TMSB4X TUBB ZNF512B	5 interacting genes: ERG HDLBP TGM2 UBE2I XPO1
Entrez ID		7052	103
HPRD ID		01825	07528
Ensembl ID		ENSG00000198959	ENSG00000160710
Uniprot IDs		B4DIT7 B4DTN7 P21980 V9HWG3	P55265
PDB IDs		1FAU 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S 4PYG 6A8P	1QBJ 1QGP 1XMK 2ACJ 2GXB 2L54 2MDR 3F21 3F22 3F23 3IRQ 3IRR 5ZU1 5ZUO 5ZUP
Enriched GO Terms of Interacting Partners?
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