TF and IGF2

Number of citations of the paper that reports this interaction (PubMedID 11749962)
9

Data Source:
BioGRID (pull down, pull down)

		TF	IGF2
Description		transferrin	insulin like growth factor 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Early Endosome Late Endosome Endoplasmic Reticulum Lumen Clathrin-coated Pit Basal Plasma Membrane Cell Surface Endosome Membrane Apical Plasma Membrane Endocytic Vesicle Clathrin-coated Vesicle Membrane Extrinsic Component Of External Side Of Plasma Membrane Cytoplasmic Vesicle Vesicle Secretory Granule Lumen Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Blood Microparticle HFE-transferrin Receptor Complex	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen
	Molecular Function	Protein Binding Ferrous Iron Binding Ferric Iron Binding Ferric Iron Transmembrane Transporter Activity Iron Chaperone Activity Transferrin Receptor Binding	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Integrin Binding Hormone Activity Protein Binding Growth Factor Activity Protein Serine/threonine Kinase Activator Activity Receptor Ligand Activity
	Biological Process	Retina Homeostasis Platelet Degranulation Cellular Iron Ion Homeostasis Actin Filament Organization Activation Of JUN Kinase Activity Response To Bacterium Osteoclast Differentiation Regulation Of Protein Stability Transferrin Transport Iron Ion Transmembrane Transport Regulation Of Iron Ion Transport Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Bone Resorption Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Receptor-mediated Endocytosis Iron Ion Homeostasis SMAD Protein Signal Transduction Membrane Organization ERK1 And ERK2 Cascade Cellular Response To Iron Ion Trivalent Inorganic Cation Transport Positive Regulation Of Cell Motility	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Differentiation In Utero Embryonic Development Embryonic Placenta Development Positive Regulation Of Protein Phosphorylation Platelet Degranulation Glucose Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Regulation Of Transcription, DNA-templated Multicellular Organism Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Animal Organ Morphogenesis Exocrine Pancreas Development Regulation Of Histone Modification Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Cellular Protein Metabolic Process Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Striated Muscle Cell Differentiation Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Embryonic Placenta Morphogenesis Spongiotrophoblast Cell Proliferation Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Glycogen (starch) Synthase Activity
Pathways		Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Post-translational protein phosphorylation Iron uptake and transport Transferrin endocytosis and recycling	Platelet degranulation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs		Cisplatin Isoflurophate Aluminium Iron Zinc Manganese Copper Chromium
Diseases			Beckwith-Wiedemann syndrome Russell-Silver syndrome; Silver-Russell syndrome Adrenal carcinoma
GWAS		Alcohol consumption (transferrin glycosylation) ( 21665994) Blood protein levels ( 30072576) Hepcidin levels ( 21785125) Hereditary hemochromatosis-related traits (HFE mutation homozygotes) ( 25457201) Iron status biomarkers ( 25224454 21483845 21208937 19084217) Iron status biomarkers (iron levels) ( 28334935 25352340) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 28334935 25352340) Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular hemoglobin concentration ( 29403010 27863252) Mean corpuscular volume ( 27863252) Metabolite levels ( 23823483) Red cell distribution width ( 27863252)	Birth weight ( 27680694) Celiac disease ( 23936387) Creatinine levels ( 29403010) DNA methylation (variation) ( 23725790) Estimated glomerular filtration rate ( 31015462 30604766) Femoral neck bone geometry and menarche (age at onset) ( 23593202) Glomerular filtration rate ( 29403010) Length of menstrual cycle ( 30202859) Prostate cancer ( 19767753) Pursuit maintenance gain ( 29064472) Type 2 diabetes ( 30297969 30718926) Urate levels ( 31578528)
Interacting Genes		20 interacting genes: CALR CANX CUBN GRB2 IGF1 IGF2 IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 LAMC3 SH3BP2 SMAD3 TFR2 TFRC TIMELESS TUBB3 VKORC1	22 interacting genes: BAG6 CCN3 CCN5 FAF1 GPC3 IDE IGF1R IGF2R IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 INSR NMRK2 PCSK4 PLG RBPMS TF VTN
Entrez ID		7018	3481
HPRD ID		01811	00939
Ensembl ID		ENSG00000091513	ENSG00000167244
Uniprot IDs		A0PJA6 P02787 Q06AH7	E3UN46 P01344
PDB IDs		1A8E 1A8F 1B3E 1BP5 1BTJ 1D3K 1D4N 1DTG 1FQE 1FQF 1JQF 1N7W 1N7X 1N84 1OQG 1OQH 1RYO 1SUV 2HAU 2HAV 2O7U 2O84 3FGS 3QYT 3S9L 3S9M 3S9N 3SKP 3V83 3V89 3V8X 3VE1 4H0W 4X1B 4X1D 5DYH 5H52 5WTD 5X5P 5Y6K 6CTC 6D03 6D04 6D05 6SOY 6SOZ	1GF2 1IGL 2L29 2V5P 3E4Z 3KR3 5L3L 5L3M 5L3N
Enriched GO Terms of Interacting Partners?
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