TERF2 and XRCC6

Number of citations of the paper that reports this interaction (PubMedID 10984620)
47

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		TERF2	XRCC6
Description		telomeric repeat binding factor 2	X-ray repair cross complementing 6
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Nuclear Body Mre11 Complex Shelterin Complex Axon Cytoplasm	Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Extracellular Region Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Membrane Protein-containing Complex Protein-DNA Complex Secretory Granule Lumen Ku70:Ku80 Complex Nonhomologous End Joining Complex Ficolin-1-rich Granule Lumen
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Double-stranded Telomeric DNA Binding Telomerase Activity Protein Binding Protein C-terminus Binding Enzyme Binding Telomeric DNA Binding Protein Homodimerization Activity Protein-containing Complex Binding G-rich Strand Telomeric DNA Binding	DNA Binding DNA Helicase Activity Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding RNA Binding Protein Binding ATP Binding Protein C-terminus Binding Cyclin Binding Telomeric DNA Binding Transcription Regulatory Region DNA Binding Protein-containing Complex Binding 5'-deoxyribose-5-phosphate Lyase Activity
	Biological Process	Telomere Maintenance RNA-dependent DNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Cell Cycle Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Telomere Capping Telomeric Loop Formation Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Recombination Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Nitric-oxide Synthase Activity Telomeric D-loop Disassembly Protein Localization To Chromosome, Telomeric Region Cellular Senescence Anterograde Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Beta-galactosidase Activity Negative Regulation Of Telomere Single Strand Break Repair Negative Regulation Of Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of T-circle Formation Negative Regulation Of Exonuclease Activity Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Cellular Senescence	Telomere Maintenance Activation Of Innate Immune Response DNA Ligation Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Brain Development Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Neutrophil Degranulation Innate Immune Response Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Smooth Muscle Cell Proliferation Cellular Hyperosmotic Salinity Response Cellular Response To Gamma Radiation Cellular Response To X-ray Establishment Of Integrated Proviral Latency Double-strand Break Repair Via Classical Nonhomologous End Joining
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase DNA Damage/Telomere Stress Induced Senescence	2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Logical memory (delayed recall) in normal cognition ( 29274321) Pulse pressure ( 30578418)	Breast cancer ( 29059683) Neuroticism ( 29255261) Pulse pressure ( 28135244)
Interacting Genes		59 interacting genes: AFAP1L2 ANXA5 APEX1 ASS1 ATM BANP BARD1 BLM CCDC137 CTBP1 DDX21 DDX24 EP300 GNMT H2AX HDGFL2 HEXIM1 HEXIM2 HMGB1 HMGN1 HMGN2 HMGN3 HMGN4 LANCL2 LYAR MAGOHB NAIF1 NASP NCL NUMA1 NUMB NUTF2 NXNL1 OCM2 ORC3 ORC6 PIAS1 PIK3R3 PPM1G PRMT1 PTMA RNF113A RNF4 RPL13 RPRD1B SET SIAH1 SP100 SRSF6 TALDO1 TERF2IP TINF2 TMSB10 TOR1AIP1 UBE2I WDR4 WRN XRCC6 ZC3H18	131 interacting genes: ABCD4 ABL1 ACD ADCY7 APEX1 AR ARAP1 ATP23 ATP6V1E1 BARD1 BAZ1A BTG1 CAPN11 CBX5 CCNA1 CCT3 CD40 CDCA5 CDK2 CDKN1A CEBPA CENPU CHAF1A CHEK1 CLTC CLU CMTM6 COIL COPB1 CREBBP CSNK2A1 CTBP2 DLX2 DNTT EFNA1 EGFR EID1 ELF3 EP300 EPS8 ETS1 FMNL1 GAL3ST4 GSE1 GZMA GZMB HERPUD1 HMGA2 HOXB7 HOXC4 HOXD4 HSF1 HTT ILVBL JPT2 KAT2A KAT2B KIAA0408 LIG3 MAP2K5 MAP4K2 MAPK8 MRE11 MSX2 NAA15 NCF4 NCL NCOA6 NIT1 NOTCH1 PAEP PAFAH1B3 PARP1 PCNA PDK1 PDPK1 PDX1 PECAM1 PGAM1 PGR PIN1 PLGRKT PNRC2 POR POU2F1 POU2F2 PRKDC PRPF40A PTTG1 QRSL1 RASA1 RBBP4 RGS2 RNF126 RNF146 RPLP1 RPS10 RRAS2 RUNX2 SDHC SELENOF SERPINA2 SERPINB9 SET SGO1 SIRT3 SKIL SMAD3 SMAD7 SNTA1 SNU13 SPARC SUMO2 TAC1 TADA3 TBCD TCF4 TERF2 TERF2IP TERT TOP1 TP53 UBC VAV1 VBP1 WBP4 WRN XRCC5 YWHAZ ZBTB7A ZNF512B
Entrez ID		7014	2547
HPRD ID		03610	01071
Ensembl ID		ENSG00000132604	ENSG00000196419
Uniprot IDs		Q15554	A0A024R1N4 B1AHC9 B4DE32 B4E356 P12956
PDB IDs		1H6P 1VF9 1VFC 1W0U 1XG1 3BU8 3BUA 3K6G 3SJM 4M7C 4RQI 5WQD 5XYF 6J67	1JEQ 1JEY 1JJR 3RZX 5Y3R 6ERF 6ERG 6ERH
Enriched GO Terms of Interacting Partners?
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