BTG1 and CNOT8

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid, pull down, two hybrid)
HPRD (in vitro)

		BTG1	CNOT8
Description		BTG anti-proliferation factor 1	CCR4-NOT transcription complex subunit 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	P-body Intracellular Nucleus Cytosol CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	Transcription Coregulator Activity Protein Binding Enzyme Binding Kinase Binding	3'-5'-exoribonuclease Activity DNA-binding Transcription Factor Activity RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Proliferation Cell Migration Negative Regulation Of Cell Growth Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Fibroblast Apoptotic Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Transcription, DNA-templated Regulation Of Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cell Proliferation Negative Regulation Of Translation Gene Silencing By MiRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		FOXO-mediated transcription of cell cycle genes	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS		Heart failure ( 20445134) Metabolite levels ( 23823483) Schizophrenia ( 28991256 29483656 30285260)
Interacting Genes		13 interacting genes: CCNA2 CDKN2D CNOT7 CNOT8 HOXB9 PRMT1 RARA RNF181 SKP2 THRA THRB TUBA1A XRCC6	9 interacting genes: BTG1 BTG2 CNOT1 CNOT2 CNOT3 CNOT4 CNOT6 PRMT1 TOB2
Entrez ID		694	9337
HPRD ID		15912	07225
Ensembl ID		ENSG00000133639	ENSG00000155508
Uniprot IDs		P62324 Q6IBC8	B7Z9U0 Q9UFF9
PDB IDs
Enriched GO Terms of Interacting Partners?
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