ZEB1 and USP51

Number of citations of the paper that reports this interaction (PubMedID 29119051)
8

Data Source:
BioGRID (pull down)

		ZEB1	USP51
Description		zinc finger E-box binding homeobox 1	ubiquitin specific peptidase 51
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytosol	Chromosome
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding E-box Binding	Chromatin Binding Thiol-dependent Ubiquitin-specific Protease Activity Zinc Ion Binding Histone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Central Nervous System Development Negative Regulation Of Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Morphogenesis Embryonic Skeletal System Morphogenesis Semicircular Canal Morphogenesis Regulation Of Smooth Muscle Cell Differentiation Cartilage Development Cellular Response To Amino Acid Stimulus Cochlea Morphogenesis	DNA Repair Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Regulation Of Double-strand Break Repair Via Homologous Recombination Histone Deubiquitination Protein Deubiquitination Regulation Of Response To DNA Damage Stimulus Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Interleukin-4 and Interleukin-13 signaling
Drugs
Diseases		Posterior polymorphous corneal dystrophy (PPCD) Fuchs corneal dystrophy (FECD); Fuchs endothelial corneal dystrophy
GWAS		Pulse pressure ( 28135244) Uterine fibroids ( 31649266) Waist-hip ratio ( 20935629) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Educational attainment (years of education) ( 30038396) Mean corpuscular volume ( 29403010) Smoking initiation ( 24665060)
Interacting Genes		12 interacting genes: ATM CDK6 CTBP1 CTBP2 DRAP1 EP300 ITGB1 KAT5 SMAD2 SMAD3 SMAD7 USP51	8 interacting genes: H2AC20 H2AC4 H2BC3 PJA1 USP15 USP21 USP28 ZEB1
Entrez ID		6935	158880
HPRD ID		01798	07167
Ensembl ID		ENSG00000148516	ENSG00000247746
Uniprot IDs		B2RBI8 B4DGU2 P37275	Q70EK9
PDB IDs		2E19
Enriched GO Terms of Interacting Partners?
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