HNF1A and RYR3

Number of citations of the paper that reports this interaction (PubMedID 20195357)
30

Data Source:
BioGRID (pull down)

		HNF1A	RYR3
Description		HNF1 homeobox A	ryanodine receptor 3
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Cytoplasm Protein-containing Complex	Cell Smooth Endoplasmic Reticulum Plasma Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Z Disc Cytoplasmic Vesicle Membrane Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding Protein Dimerization Activity	Ryanodine-sensitive Calcium-release Channel Activity Calcium Ion Binding Calmodulin Binding Calcium-release Channel Activity Calcium-induced Calcium Release Activity
	Biological Process	Natural Killer Cell Differentiation Liver Development Regulation Of Transcription By RNA Polymerase II Insulin Secretion Pancreas Development Regulation Of Pronephros Size Renal Glucose Absorption Glucose Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Glucose Import Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter	Calcium Ion Transport Ion Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Negative Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To Magnesium Ion Cellular Response To Caffeine Cellular Response To ATP Regulation Of Cardiac Conduction
Pathways		Regulation of gene expression in beta cells	Stimuli-sensing channels Ion homeostasis
Drugs		D-norleucine
Diseases		Maturity onset diabetes of the young (MODY)
GWAS		Acute insulin response ( 28490609) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Birth weight ( 31043758) Blood protein levels in cardiovascular risk ( 28369058) Blood urea nitrogen levels ( 29403010) C-reactive protein ( 19567438 21647738 18439548 18439552 21196492 23844046 22939635) C-reactive protein and white blood cell count ( 22788528) C-reactive protein levels ( 24763700 29403010 30388399 21300955) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Chloride levels ( 29403010) Cholesterol, total ( 24097068 25961943 20686565) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Coronary artery disease ( 29212778 30104761 28714974) Coronary heart disease ( 19198612) Gallstone disease ( 30504769) Gamma glutamyl transferase levels ( 29403010 22010049) Gamma glutamyl transpeptidase ( 21909109) Glucosuria ( 30476138) Glucosuria (moderate to severe) ( 30476138) HDL cholesterol levels ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Homocysteine levels ( 23824729) Insulinogenic index ( 23263489) LDL cholesterol ( 24097068 19060906 30275531 25961943 20686565) LDL cholesterol levels ( 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Liver enzyme levels ( 18940312) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Longevity ( 20834067) N-glycan levels ( 21908519 21203500) Pancreatic cancer ( 29422604 26098869) Pancreatic ductal adenocarcinoma ( 30541042) Peak insulin response ( 28490609) Serum alkaline phosphatase levels ( 31666285) Serum alpha1-antitrypsin levels ( 26174136) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 28334899 30275531) Type 2 diabetes ( 21573907 22885922 24509480 30297969 29632382 26818947 20581827 30718926 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382) Urate levels ( 31578528 23263486) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Carotid atherosclerosis in HIV infection ( 20009918) Hepcidin/ferritin ratio ( 27846281) Hippocampal volume ( 31530798) Periodontitis (Mean PAL) ( 24024966) Schizophrenia ( 30285260)
Interacting Genes		24 interacting genes: ALB BCR CDX2 CEBPA CREBBP CTNNB1 EP300 FOS GATA5 HNF1B HNF4A KAT2B MYOG NCOA1 NCOA3 PCBD1 POU2F1 RAC3 RNF14 RYR3 SRC STAT3 TLE1 TLE5	5 interacting genes: BCL2L1 FKBP1A FKBP1B HNF1A RYR2
Entrez ID		6927	6263
HPRD ID		00800	01620
Ensembl ID		ENSG00000135100	ENSG00000198838
Uniprot IDs		E0YMI7 P20823	A0A0U1RRH1 Q15413
PDB IDs		1IC8 2GYP	4ERV
Enriched GO Terms of Interacting Partners?
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