VAMP2 and STXBP2

Number of citations of the paper that reports this interaction (PubMedID 12773094)
24

Data Source:
HPRD (in vitro)

		VAMP2	STXBP2
Description		vesicle associated membrane protein 2	syntaxin binding protein 2
Image
GO Annotations	Cellular Component	Trans-Golgi Network Cytosol Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Membrane Cell Junction Clathrin-coated Vesicle Secretory Granule Clathrin-coated Vesicle Membrane Secretory Granule Membrane Synaptic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Vesicle Zymogen Granule Membrane Neuron Projection Intracellular Membrane-bounded Organelle Neuron Projection Terminus Synapse Perinuclear Region Of Cytoplasm Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Clathrin-sculpted Monoamine Transport Vesicle Membrane	Extracellular Region Cytosol Plasma Membrane Apical Plasma Membrane Specific Granule Azurophil Granule Zymogen Granule Membrane Cytolytic Granule Phagocytic Vesicle Extracellular Exosome Tertiary Granule
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Calmodulin Binding Phospholipid Binding Syntaxin-1 Binding Syntaxin Binding Protein Self-association Calcium-dependent Protein Binding	Protein Binding Syntaxin-1 Binding Syntaxin-3 Binding
	Biological Process	Exocytosis Post-Golgi Vesicle-mediated Transport Vesicle Fusion Neurotransmitter Secretion Response To Glucose Glutamate Secretion Protein Transport Synaptic Vesicle Exocytosis Vesicle-mediated Transport Calcium Ion Regulated Exocytosis Regulation Of Exocytosis Cellular Response To Insulin Stimulus SNARE Complex Assembly Golgi To Plasma Membrane Protein Transport Eosinophil Degranulation Neutrophil Degranulation Natural Killer Cell Degranulation Long-term Synaptic Potentiation Regulation Of Vesicle-mediated Transport Membrane Organization Membrane Fusion Protein-containing Complex Assembly Mucus Secretion Positive Regulation Of Intracellular Protein Transport Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Histamine Secretion By Mast Cell	Leukocyte Mediated Cytotoxicity Platelet Degranulation Vesicle Docking Involved In Exocytosis Protein Transport Regulation Of Mast Cell Degranulation Neutrophil Degranulation Cellular Response To Interferon-gamma
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle trans-Golgi Network Vesicle Budding Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Insulin processing Regulation of insulin secretion Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Other interleukin signaling Toxicity of botulinum toxin type D (BoNT/D) Toxicity of botulinum toxin type B (BoNT/B) Toxicity of botulinum toxin type F (BoNT/F) Toxicity of tetanus toxin (TeNT) Toxicity of botulinum toxin type G (BoNT/G) Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis GABA synthesis, release, reuptake and degradation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Platelet degranulation Other interleukin signaling
Drugs		Botulinum Toxin Type B
Diseases
GWAS		Chronotype ( 30696823) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Morning person ( 30696823) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		28 interacting genes: ATP13A2 BAG6 BCAP31 CPLX1 EXOC3 FKBP2 GET3 LMNA PRKD3 RABAC1 SLC6A4 SNAP23 SNAP25 SNAP29 STX11 STX1A STX1B STX4 STXBP2 STXBP3 SYP SYPL1 TRPC3 VAMP3 VAMP8 VAPA VAPB VCP	13 interacting genes: DDX20 GEMIN2 GEMIN4 SMN1 SNAP23 SNRPB SNRPD2 SNRPD3 STX1A STX2 STX3 STXBP3 VAMP2
Entrez ID		6844	6813
HPRD ID		01717	03423
Ensembl ID		ENSG00000220205	ENSG00000076944
Uniprot IDs		F8WCA0 P63027	Q15833 Q53GF4
PDB IDs		3FIE 3FII 3RK2 3RK3 3RL0	4CCA
Enriched GO Terms of Interacting Partners?
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