STK11 and HGF

Number of citations of the paper that reports this interaction (PubMedID 28205554)
32

Data Source:
BioGRID (fluorescent resonance energy transfer)

		STK11	HGF
Description		serine/threonine kinase 11	hepatocyte growth factor
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Membrane Extracellular Exosome	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen
	Molecular Function	Magnesium Ion Binding P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding LRR Domain Binding Protein Kinase Activator Activity	Serine-type Endopeptidase Activity Protein Binding Growth Factor Activity Chemoattractant Activity Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Regulation Of Cell Growth Tissue Homeostasis Vasculature Development Protein Phosphorylation Protein Dephosphorylation Autophagy Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Spermatogenesis Axonogenesis Negative Regulation Of Cell Proliferation Response To Ionizing Radiation Positive Regulation Of Autophagy Establishment Of Cell Polarity Negative Regulation Of Cell Growth Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Protein Kinase Activity Glucose Homeostasis Anoikis Positive Thymic T Cell Selection Protein Autophosphorylation Regulation Of Dendrite Morphogenesis Positive Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Golgi Localization Regulation Of Protein Kinase B Signaling Canonical Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To UV-B Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Canonical Wnt Signaling Pathway Dendrite Extension Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Protein Localization To Nucleus Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of TORC1 Signaling	MAPK Cascade Activation Of MAPK Activity Mitotic Cell Cycle Cell Morphogenesis Epithelial To Mesenchymal Transition Liver Development Positive Regulation Of Protein Phosphorylation Platelet Degranulation Proteolysis Negative Regulation Of Autophagy Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cytokine-mediated Signaling Pathway Hyaluronan Metabolic Process Positive Regulation Of Cell Migration Animal Organ Regeneration Positive Regulation Of Myelination Negative Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-10 Production Negative Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Growth Factor Receptor Signaling Pathway Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Myoblast Proliferation Positive Regulation Of Protein Kinase B Signaling Cell Chemotaxis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Positive Regulation Of Neuron Projection Regeneration Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of P38MAPK Cascade Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Tau-protein Kinase Activity Positive Regulation Of DNA Biosynthetic Process
Pathways		AMPK inhibits chREBP transcriptional activation activity Energy dependent regulation of mTOR by LKB1-AMPK Regulation of TP53 Activity through Phosphorylation FOXO-mediated transcription of cell death genes	Platelet degranulation PIP3 activates AKT signaling Interleukin-7 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling MET Receptor Activation Negative regulation of MET activity PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates RAS signaling MET activates PI3K/AKT signaling MET activates PTPN11 MET activates PTK2 signaling MET interacts with TNS proteins MET activates RAP1 and RAC1 MET receptor recycling MET activates STAT3
Drugs			Heparin O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine ABT-510 Foretinib
Diseases		Peutz-Jeghers syndrome Pancreatic cancer
GWAS		Asthma (childhood onset) ( 31036433) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 27863252) Psychosis in Alzheimer's disease ( 22005930)	Blood protein levels ( 30072576 29875488) Endothelial growth factor levels ( 25552591) Gestational age at birth (maternal effect) ( 28598419) Gout ( 22179738) Hepatocyte growth factor levels ( 27989323) Intraocular pressure ( 29785010 29235454) Rosacea symptom severity ( 29771307) Spontaneous preterm birth (maternal effect) ( 28598419) Transverse temporal cortex volume ( 31530798) Tuberculosis ( 29036319)
Interacting Genes		113 interacting genes: ABCB5 ADIPOR1 AKT1 APP ARAF ARG2 ARNT ATM AURKA BCAS3 BECN1 BRAF CAB39 CALM2 CBLC CCND2 CCNE1 CD44 CDC37 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CFL2 CRY2 CTSB CYP17A1 D2HGDH DACH1 EEF1A2 EPHA2 ERBB2 ERLEC1 ETV4 FAIM2 FGFR4 FZR1 GLIS2 GNPDA1 GRM1 HERC2 HGF HIF1A KAT2A KDELR2 KLK7 LATS2 LYPD3 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MAPK14 MAPRE1 MARK1 MARK2 MARK4 MDM2 MET MOB4 MOCS2 MT-ND2 MYC NAT2 NF2 PARD3 PDGFRA PDXP PHF23 PIK3CA PLD3 PRKAA1 PRKAA2 PRKACA PRSS50 PTEN RASSF1 RHOBTB2 RPS6KA3 RPS6KA5 RPS6KB1 S100A14 SEPTIN9 SERPINB5 SIK1 SIRT1 SMAD1 SMARCA4 SNRK SOX4 SPDEF ST14 STK11IP STK24 STRADA STRADB TBC1D23 TEAD2 TERT THOP1 THRSP TNFRSF1A TNIP2 TP53 TRIM25 TSG101 TUBA1A TUBB4A UBE2D2 VPS72 WT1 YWHAG	37 interacting genes: ADAMTSL4 ARNT BRCA1 CCND2 CDK4 CDK6 CDKN2A CDKN2B CLEC3B EPHA2 ERBB2 F11 FGFR4 FN1 GLIS2 HGFAC HPN KLKB1 LATS2 LCN2 MAP2K5 MAP2K6 MDM4 MEOX2 MET MYC NF2 PDGFRA PLAU RAF1 SDC1 SDC2 ST14 STK11 TEAD2 VTN YWHAG
Entrez ID		6794	3082
HPRD ID		03740	00799
Ensembl ID		ENSG00000118046	ENSG00000019991
Uniprot IDs		A0A0S2Z4D1 Q15831	P14210
PDB IDs		2WTK 4ZDR 5WXN	1BHT 1GMN 1GMO 1GP9 1NK1 1SHY 1SI5 2HGF 2QJ2 3HMS 3HMT 3HN4 3MKP 3SP8 4D3C 4K3J 4O3T 4O3U 5COE 5CP9 5CS1 5CS3 5CS5 5CS9 5CSQ 5CT1 5CT2 5CT3
Enriched GO Terms of Interacting Partners?
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