SSTR2 and SHANK1

Number of citations of the paper that reports this interaction (PubMedID 10551867)
27

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vitro, two hybrid, in vivo)

		SSTR2	SHANK1
Description		somatostatin receptor 2	SH3 and multiple ankyrin repeat domains 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection	Cell Cytosol Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Cell Junction Dendrite Neuron Projection Dendritic Spine Neuron Spine Postsynaptic Membrane Excitatory Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	G Protein-coupled Receptor Activity Somatostatin Receptor Activity Protein Binding PDZ Domain Binding Peptide Binding Neuropeptide Binding	Protein Binding Protein C-terminus Binding SH3 Domain Binding Receptor Signaling Complex Scaffold Activity GKAP/Homer Scaffold Activity Somatostatin Receptor Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Ankyrin Repeat Binding Scaffold Protein Binding
	Biological Process	Regulation Of Muscle Contraction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Spermatogenesis Negative Regulation Of Cell Proliferation Cerebellum Development Peristalsis Forebrain Development Somatostatin Signaling Pathway Response To Starvation Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus	Cytoskeletal Anchoring At Plasma Membrane Synapse Assembly Behavior Long-term Memory Associative Learning Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Protein Localization To Synapse Olfactory Behavior Habituation Brain Morphogenesis Neuromuscular Process Controlling Balance Determination Of Affect Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synaptic Transmission, Glutamatergic Righting Reflex Synapse Maturation Long-term Synaptic Potentiation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Vocalization Behavior Postsynaptic Density Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Neurexins and neuroligins Neurexins and neuroligins
Drugs		Octreotide Vapreotide Pasireotide Lanreotide Dotatate gallium Ga-68
Diseases
GWAS		Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Metabolite levels ( 23823483)	Clozapine-induced cytotoxicity ( 25656473)
Interacting Genes		10 interacting genes: APP CORT DRD2 GNA14 GNAI1 PIK3R1 PTPN6 SHANK1 SHANK2 SST	18 interacting genes: ABCA1 ADGRB2 ADGRL1 ADGRL2 ARHGEF7 BAIAP2 DLG4 DLGAP1 DNM2 HOMER1 RPS6KA2 RPS6KA3 SHARPIN SPTAN1 SSTR2 STAT1 TANC1 USP8
Entrez ID		6752	50944
HPRD ID		01674	05413
Ensembl ID		ENSG00000180616	ENSG00000161681
Uniprot IDs		P30874	H9KV90 Q9Y566
PDB IDs			6CPI
Enriched GO Terms of Interacting Partners?
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