SPTA1 and ADD1

Number of citations of the paper that reports this interaction (PubMedID 3600811)
72

Data Source:
HPRD (in vitro)

		SPTA1	ADD1
Description		spectrin alpha, erythrocytic 1	adducin 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Spectrin Spectrin-associated Cytoskeleton Actin Cytoskeleton Axon Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Cuticular Plate	Cell Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion F-actin Capping Protein Complex Postsynaptic Density Nuclear Body Plasma Membrane Raft
	Molecular Function	Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Actin Filament Binding	RNA Binding Actin Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Calmodulin Binding Transcription Factor Binding Spectrin Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Actin Filament Binding
	Biological Process	MAPK Cascade Lymphocyte Homeostasis Porphyrin-containing Compound Biosynthetic Process ER To Golgi Vesicle-mediated Transport Plasma Membrane Organization Actin Filament Organization Axon Guidance Regulation Of Cell Shape Hemopoiesis Positive Regulation Of Protein Binding Positive Regulation Of T Cell Proliferation Actin Filament Capping	Cell Morphogenesis In Utero Embryonic Development Cell Volume Homeostasis Hemoglobin Metabolic Process Actin Cytoskeleton Organization Erythrocyte Differentiation Positive Regulation Of Protein Binding Multicellular Organism Growth IRE1-mediated Unfolded Protein Response Homeostasis Of Number Of Cells Within A Tissue Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Transmembrane Transport Cellular Response To Calcium Ion Positive Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Adherens Junction Organization
Pathways		NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport	Caspase-mediated cleavage of cytoskeletal proteins XBP1(S) activates chaperone genes Miscellaneous transport and binding events
Drugs
Diseases		Hereditary elliptocytosis (HE) Hereditary spherocytosis (SPH)
GWAS		Glycated hemoglobin levels ( 20858683 28898252) Hemoglobin A1c levels ( 29844224) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Lymphocyte counts ( 27863252) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular hemoglobin concentration ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252) Neutrophil percentage of white cells ( 27863252) Night sleep phenotypes ( 27126917) Other erythrocyte phenotypes ( 19862010) QRS duration ( 27577874) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)	Household income ( 31844048) Household income (MTAG) ( 31844048) Huntington's disease progression ( 28642124)
Interacting Genes		15 interacting genes: ABI1 ABL1 ACTA1 ADD1 ANK1 ENAH EVL FANCC FASLG PLEC SLC9A2 SPTB SPTBN2 VASP YWHAQ	21 interacting genes: ADD2 ATP1A1 CALM1 CASP3 CSNK2B GEMIN7 HMG20A HSPH1 ID2 ID3 MAP1LC3B PRKACA PRKCA PRKCD RFX1 ROCK1 SMARCC1 SPTA1 SPTB TK1 ZDHHC17
Entrez ID		6708	118
HPRD ID		01685	00036
Ensembl ID		ENSG00000163554	ENSG00000087274
Uniprot IDs		P02549	P35611
PDB IDs		1OWA 3LBX 5J4O
Enriched GO Terms of Interacting Partners?
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