SPINT1 and NLGN3

Number of citations of the paper that reports this interaction (PubMedID 25464930)
5

Data Source:
BioGRID (two hybrid)

		SPINT1	NLGN3
Description		serine peptidase inhibitor, Kunitz type 1	neuroligin 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Cell Junction Endocytic Vesicle Synapse Excitatory Synapse Spanning Component Of Membrane Presynapse Symmetric, GABA-ergic, Inhibitory Synapse Asymmetric, Glutamatergic, Excitatory Synapse Integral Component Of Postsynaptic Membrane
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Protein Binding Signaling Receptor Activity Neurexin Family Protein Binding Cell Adhesion Molecule Binding Scaffold Protein Binding
	Biological Process	Neural Tube Closure Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Positive Regulation Of Glial Cell Differentiation Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Cellular Response To BMP Stimulus Negative Regulation Of Neural Precursor Cell Proliferation	Regulation Of Respiratory Gaseous Exchange By Neurological System Process Receptor-mediated Endocytosis Neuron Cell-cell Adhesion Chemical Synaptic Transmission Synapse Assembly Learning Visual Learning Adult Behavior Social Behavior Synaptic Vesicle Endocytosis Axon Extension Oligodendrocyte Differentiation Modulation Of Chemical Synaptic Transmission Synapse Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Rhythmic Synaptic Transmission Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential Long-term Synaptic Potentiation Negative Regulation Of Dendritic Spine Morphogenesis Vocalization Behavior Negative Regulation Of Excitatory Postsynaptic Potential Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynapse Assembly Regulation Of Long-term Synaptic Potentiation Regulation Of NMDA Receptor Activity Regulation Of Terminal Button Organization Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Vesicle Clustering Positive Regulation Of AMPA Receptor Activity
Pathways		MET Receptor Activation Signaling by MST1	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Prostate cancer ( 25217961)
Interacting Genes		6 interacting genes: HGFAC HMGB1 NLGN3 ST14 TENT5A UBQLN4	56 interacting genes: ALPP AP2A2 ATF4 C1orf122 C1QA CCAR2 CGB3 CTSD DLG2 DLG3 DLG4 DPEP2 EBPL EFS FANCG FBLN1 FHOD1 FKBP1A FLNA GDF15 GUK1 HID1 ITPRIP LGALS1 MAN2C1 MAP1S MEOX2 MIEN1 NFATC4 NRDC NRXN1 NRXN2 NRXN3 OAZ1 OR1F12 PDZD11 PKIB PLB1 PLCB4 PRDX2 PSAP PSG1 PSG11 PSG3 PSG4 PSG5 QARS1 SPAG5 SPINT1 SSR4 TNNT3 TRIM33 TXNIP UBQLN1 UBXN6 UQCRC1
Entrez ID		6692	54413
HPRD ID		05494	02275
Ensembl ID		ENSG00000166145	ENSG00000196338
Uniprot IDs		O43278	B7Z3P8 Q4G160 Q6MZK0 Q9NZ94 X5D2P6 X5D7L6 X5DNV3
PDB IDs		1YC0 2MSX 4ISL 4ISN 4ISO 5EZD 5H7V
Enriched GO Terms of Interacting Partners?
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