SP3 and GABPA

Number of citations of the paper that reports this interaction (PubMedID 11237613)
19

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vivo)

		SP3	GABPA
Description		Sp3 transcription factor	GA binding protein transcription factor subunit alpha
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm PML Body Transcriptional Repressor Complex Protein-DNA Complex	Nuclear Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Metal Ion Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Activating Transcription Factor Binding Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Natural Killer Cell Differentiation Trophectodermal Cell Differentiation Liver Development Embryonic Placenta Development Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II B Cell Differentiation T Cell Differentiation Megakaryocyte Differentiation Monocyte Differentiation Lung Development Granulocyte Differentiation Enucleate Erythrocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Morphogenesis Embryonic Skeletal System Development Embryonic Process Involved In Female Pregnancy Definitive Hemopoiesis	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Formation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Mitochondrion Organization Positive Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Dopamine
Pathways		SUMOylation of transcription factors	Transcriptional activation of mitochondrial biogenesis
Drugs
Diseases
GWAS		End-stage renal disease in Type 1 diabetics ( 24029427) Lung cancer ( 28604730) Male-pattern baldness ( 27182965) Mosquito bite size ( 28199695) Otitis media (chronic/recurrent) ( 23974705) QT interval ( 24952745) Sensation seeking ( 30718321)
Interacting Genes		23 interacting genes: AKT1 E2F1 EP300 ESR1 GABPA GCH1 GRIN1 HDAC1 HDAC2 HLTF NKX3-1 PIAS1 RB1 RBBP4 RPS20 SP1 STK19 SUMO1 TP53 TP73 UBE2I VEGFA ZBTB7A	10 interacting genes: APP ATF1 CREBBP EP300 GABPB1 HCFC1 MED1 PINX1 SP1 SP3
Entrez ID		6670	2551
HPRD ID		03483	11793
Ensembl ID		ENSG00000172845	ENSG00000154727
Uniprot IDs		B7ZLN9 Q02447 Q59FX5 Q86TP0	A8IE48 Q06546 Q8IYS3
PDB IDs
Enriched GO Terms of Interacting Partners?
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