SOS2 and SNX18

Number of citations of the paper that reports this interaction (PubMedID 14679214)
67

Data Source:
HPRD (in vitro)

		SOS2	SNX18
Description		SOS Ras/Rho guanine nucleotide exchange factor 2	sorting nexin 18
Image			No pdb structure
GO Annotations	Cellular Component	Nucleosome Cytosol	Endosome Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Heterodimerization Activity	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction	Mitotic Cytokinesis Endocytosis Protein Transport Endosomal Transport Cleavage Furrow Formation Positive Regulation Of GTPase Activity
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Activation of RAC1 Interleukin-15 signaling	Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Birth weight ( 31043758) Erythema nodosum in inflammatory bowel disease ( 24487271) Estimated glomerular filtration rate ( 31015462) Intraocular pressure ( 29617998 29785010 31959993 30054594) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Periodontal disease-related phenotype (Socransky) ( 24347629) Pulse pressure ( 30578418)	Immune response to smallpox vaccine (IL-6) ( 22542470)
Interacting Genes		16 interacting genes: ABI1 ABL1 BIN1 CD2AP CRKL EGFR GRAP2 GRB2 HRAS ITSN2 PACSIN3 PLCG1 SH3D19 SHC1 SNX18 SNX9	2 interacting genes: SOS1 SOS2
Entrez ID		6655	112574
HPRD ID		03149	15407
Ensembl ID		ENSG00000100485	ENSG00000178996
Uniprot IDs		Q07890	Q96RF0
PDB IDs		6EIE
Enriched GO Terms of Interacting Partners?
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