BMX and TNFRSF1B

Number of citations of the paper that reports this interaction (PubMedID 12370298)
42

Data Source:
HPRD (in vitro)

		BMX	TNFRSF1B
Description		BMX non-receptor tyrosine kinase	TNF receptor superfamily member 1B
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Ruffle Membrane	Tumor Necrosis Factor Receptor Superfamily Complex Extracellular Region Nucleus Plasma Membrane Membrane Integral Component Of Membrane Specific Granule Membrane Neuronal Cell Body Varicosity Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Tumor Necrosis Factor-activated Receptor Activity Protein Binding Ubiquitin Protein Ligase Binding Tumor Necrosis Factor Binding
	Biological Process	Protein Phosphorylation Phosphatidylinositol Biosynthetic Process Apoptotic Process Cell Adhesion Signal Transduction Mesoderm Development Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Protein Autophosphorylation	Regulation Of T Cell Cytokine Production Regulation Of Cytokine Secretion Involved In Immune Response Aortic Valve Development Pulmonary Valve Development Negative Regulation Of Extracellular Matrix Constituent Secretion Inflammatory Response Aging Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cardiac Muscle Hypertrophy Cytokine-mediated Signaling Pathway Regulation Of Myelination Positive Regulation Of Myelination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of T Cell Proliferation Neutrophil Degranulation Positive Regulation Of Oligodendrocyte Differentiation RNA Destabilization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cell Death Cellular Response To Lipopolysaccharide Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Neuron Death Positive Regulation Of Apoptotic Process Involved In Morphogenesis Regulation Of RNA Biosynthetic Process
Pathways		Apoptotic cleavage of cellular proteins Synthesis of PIPs at the plasma membrane	TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation
Drugs			Etanercept
Diseases			Graft-versus-host disease
GWAS			Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Tuberculosis ( 29036319) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		25 interacting genes: APP BCAR1 BTK C12orf45 CASP3 CAV1 CLNK EGFR ERBB2 FBXO25 ITK KDR PAK1 PTK2 PTPN21 PTPRD RAP1A RUFY1 RUFY2 SRC STAT1 STAT3 STAT5A TEC TNFRSF1B	21 interacting genes: ADAM17 BMX CAV1 CD14 CSNK1A1 CSNK1A1L FANCD2 HIVEP3 KRT18 LTA PKN1 STAT1 TDP2 TNF TRAF1 TRAF2 TRAF3 TRAIP TRIM37 UBQLN1 ZNF420
Entrez ID		660	7133
HPRD ID		02111	01862
Ensembl ID		ENSG00000102010	ENSG00000028137
Uniprot IDs		P51813	P20333
PDB IDs		2EKX 2YS2 3SXR 3SXS	1CA9 3ALQ
Enriched GO Terms of Interacting Partners?
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