SLC22A5 and SLC9A3R2

Number of citations of the paper that reports this interaction (PubMedID 15553237)
12

Data Source:
HPRD (two hybrid)

		SLC22A5	SLC9A3R2
Description		solute carrier family 22 member 5	SLC9A3 regulator 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Exosome	Nucleus Plasma Membrane Focal Adhesion Endomembrane System Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding ATP Binding Carnitine Transmembrane Transporter Activity Symporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity PDZ Domain Binding Xenobiotic Transmembrane Transporter Activity	Signaling Receptor Binding Protein Binding Beta-catenin Binding Protein C-terminus Binding Phosphatase Binding Cadherin Binding Molecular Adaptor Activity
	Biological Process	Sodium Ion Transport Response To Symbiotic Bacterium Quaternary Ammonium Group Transport Carnitine Transport Positive Regulation Of Intestinal Epithelial Structure Maintenance Sodium-dependent Organic Cation Transport Carnitine Transmembrane Transport Drug Transmembrane Export	Protein-containing Complex Assembly
Pathways		Carnitine metabolism Organic cation transport Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)
Drugs		L-Carnitine
Diseases		Crohn's disease Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
GWAS		Acylcarnitine levels ( 26068415) Asthma ( 20860503 31619474 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Crohn's disease ( 28067908 21102463) Diastolic blood pressure ( 30578418) Fibrinogen ( 20031577) Height ( 20881960) Inflammatory bowel disease ( 28067908 23128233) Low density lipoprotein cholesterol levels ( 29083408) Mosquito bite size ( 28199695) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Serum metabolite levels ( 23093944) Ulcerative colitis ( 28067908)	Diastolic blood pressure ( 27841878 30578418) Pulse pressure ( 30578418) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		4 interacting genes: PDZD3 PDZK1 SLC9A3R1 SLC9A3R2	37 interacting genes: ABCC4 ACTN4 ADORA2B ADRB2 ATP2B2 CFTR EZR KCNJ1 LPAR1 LPAR2 P2RY1 PDGFRB PDPK1 PDZK1 PLCB3 PODXL PRKACA PRKCA PTEN PTH1R RDX RPS6KA1 SGK1 SGK3 SIAH1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAZ TBC1D10A WWTR1
Entrez ID		6584	9351
HPRD ID		04539	05946
Ensembl ID		ENSG00000197375	ENSG00000065054
Uniprot IDs		O76082	Q15599
PDB IDs			2D11 2HE4 2OCS 4P0C
Enriched GO Terms of Interacting Partners?
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