BMPR1B and RAB38

Number of citations of the paper that reports this interaction (PubMedID 15761153)
246

Data Source:
HPRD (in vivo)

		BMPR1B	RAB38
Description		bone morphogenetic protein receptor type 1B	RAB38, member RAS oncogene family
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Neuronal Cell Body Receptor Complex HFE-transferrin Receptor Complex	Cell Mitochondrion Lysosome Early Endosome Endoplasmic Reticulum Trans-Golgi Network Cytosol Plasma Membrane Endomembrane System Membrane Phagocytic Vesicle Membrane Early Endosome Lumen Melanosome Membrane Melanosome Mitochondria-associated ER Membrane Phagocytic Vesicle
	Molecular Function	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding SMAD Binding Metal Ion Binding	GTPase Activity Protein Binding GTP Binding GTP-dependent Protein Binding AP-2 Adaptor Complex Binding AP-1 Adaptor Complex Binding AP-3 Adaptor Complex Binding BLOC-2 Complex Binding
	Biological Process	Skeletal System Development Cartilage Condensation Ovarian Cumulus Expansion Eye Development Chondrocyte Development Protein Phosphorylation Inflammatory Response Dorsal/ventral Pattern Formation Proteoglycan Biosynthetic Process Positive Regulation Of Bone Mineralization BMP Signaling Pathway Retinal Ganglion Cell Axon Guidance Positive Regulation Of Chondrocyte Differentiation Limb Morphogenesis Ovulation Cycle Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Retina Development In Camera-type Eye Endochondral Bone Morphogenesis Positive Regulation Of Cartilage Development Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Chondrocyte Proliferation	Intracellular Protein Transport Mitochondrion Organization Small GTPase Mediated Signal Transduction Protein Transport Vesicle-mediated Transport Melanosome Organization Rab Protein Signal Transduction Endosome To Melanosome Transport Post-translational Protein Modification Platelet Dense Granule Organization Protein Localization To Membrane Phagosome Acidification Melanosome Assembly Positive Regulation Of Phosphatidylcholine Biosynthetic Process
Pathways		Signaling by BMP	RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Acromesomelic dysplasia with genital anomalies Brachydactyly, including: type A; type B; type D; type E
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Attention deficit hyperactivity disorder ( 20732626) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Diverticular disease ( 30177863) Heel bone mineral density ( 30598549) Hen's egg allergy ( 29051540) Prepulse inhibition of the startle response ( 31596458) Schizophrenia ( 30470734) Systolic blood pressure ( 30224653 30578418) Waist-hip ratio ( 28552196)	Chloride levels ( 29403010) Frontotemporal dementia ( 24943344) Gut microbiota (bacterial taxa) ( 27694959) Multiple sclerosis (age of onset) ( 19010793) Sodium levels ( 29403010) Triiodothyronine levels ( 30824882) Urinary albumin-to-creatinine ratio in diabetes ( 26631737)
Interacting Genes		64 interacting genes: AMHR2 APP ARHGEF6 BAMBI BMP15 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR2 CDK14 CDK4 CHN1 DCAF12 DCAF6 DCAF7 FANCL GDF5 GDF6 GDF9 KLHL1 LZTR1 NKIRAS1 OTUB1 OXSR1 PAK1 PLEKHB1 POMK PPP2CA PPP3CC RAB25 RAB38 RAB6B RAN RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 SASH3 SH3KBP1 SMAD6 SMAD7 SNX6 SOCS6 SQSTM1 SRGAP1 STAMBP STK35 STUB1 TGFBR1 TNNT1 TRAF6 TTC17 TTC27 UBA52 UBE2Z UBXN1 USP45 VEPH1	7 interacting genes: APP BMPR1B SMAD1 SMAD2 SMAD3 SMAD4 TGFBR1
Entrez ID		658	23682
HPRD ID		04457	05889
Ensembl ID		ENSG00000138696	ENSG00000123892
Uniprot IDs		A8KAE3 O00238	A0A024R191 P57729
PDB IDs		3MDY	6HDU
Enriched GO Terms of Interacting Partners?
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