NCF1 and SYTL1

Number of citations of the paper that reports this interaction (PubMedID 11278853)
20

Data Source:
BioGRID (pull down)

		NCF1	SYTL1
Description		neutrophil cytosolic factor 1	synaptotagmin like 1
Image			No pdb structure
GO Annotations	Cellular Component	Cell Rough Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane Extrinsic Component Of Membrane Dendrite Phagolysosome NADPH Oxidase Complex Neuronal Cell Body	Plasma Membrane Extrinsic Component Of Plasma Membrane Microvillus Membrane Melanosome Extracellular Exosome Exocytic Vesicle
	Molecular Function	Protein Binding Electron Transfer Activity Superoxide-generating NADPH Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding	Protein Binding Rab GTPase Binding Neurexin Family Protein Binding
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Protein Targeting To Membrane Superoxide Metabolic Process Apoptotic Process Cellular Defense Response Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Electron Transport Chain Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Superoxide Anion Generation Innate Immune Response Cell Redox Homeostasis Respiratory Burst Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Cadmium Ion Positive Regulation Of P38MAPK Cascade	Intracellular Protein Transport Exocytosis
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases	TBC/RABGAPs
Drugs		Dextromethorphan
Diseases		Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS
Interacting Genes		26 interacting genes: ACTB CSNK2B CYBA FASLG GAA GMNN KHDRBS1 MAPK9 MGAM MSN MYBPC1 MYBPC3 NCF4 NOXA1 PKD1 PLA2G4A PRKCA PRKCB PRKCD PRKCZ PRKDC PTEN SRSF2 SYTL1 TRAF4 TRIM9	7 interacting genes: AKT1 NCF1 NCF2 NRXN1 RAB27A RAB27B RAB8A
Entrez ID		653361	84958
HPRD ID			12156
Ensembl ID		ENSG00000158517	ENSG00000142765
Uniprot IDs		P14598	Q8IYJ3
PDB IDs		1GD5 1K4U 1KQ6 1NG2 1O7K 1OV3 1UEC 1W70 1WLP
Enriched GO Terms of Interacting Partners?
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