PINK1 and HSD17B10

Number of citations of the paper that reports this interaction (PubMedID 25591737)
8

Data Source:
BioGRID (fluorescent resonance energy transfer)

		PINK1	HSD17B10
Description		PTEN induced kinase 1	hydroxysteroid 17-beta dehydrogenase 10
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Cytosol Cytoskeleton Membrane Axon Growth Cone Integral Component Of Mitochondrial Outer Membrane Cell Body Perinuclear Region Of Cytoplasm Lewy Body Astrocyte Projection	Cytoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Mitochondrial Ribonuclease P Complex
	Molecular Function	Magnesium Ion Binding Protease Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Calcium-dependent Protein Kinase Activity Kinase Activity Peptidase Activator Activity Ubiquitin Protein Ligase Binding Protein Kinase B Binding Protein-containing Complex Binding C3HC4-type RING Finger Domain Binding TORC2 Complex Binding	TRNA Binding RNA Binding 3-hydroxyacyl-CoA Dehydrogenase Activity Protein Binding Cholate 7-alpha-dehydrogenase Activity Testosterone Dehydrogenase [NAD(P)] Activity Dihydrotestosterone 17-beta-dehydrogenase Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity
	Biological Process	Autophagy Of Mitochondrion Positive Regulation Of Protein Phosphorylation Regulation Of Oxidative Phosphorylation Response To Ischemia Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Response To Oxidative Stress Mitochondrion Organization Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Gene Expression Regulation Of Mitochondrion Organization Positive Regulation Of Peptidase Activity Macroautophagy Positive Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Protein Ubiquitination Peptidyl-serine Phosphorylation Respiratory Electron Transport Chain Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Activation Of Protein Kinase B Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Dopamine Secretion Cellular Response To Oxidative Stress Positive Regulation Of Protein Dephosphorylation Intracellular Signal Transduction Peptidyl-serine Autophosphorylation TORC2 Signaling Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Complex Assembly Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Translation Negative Regulation Of JNK Cascade Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein Kinase B Signaling Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Hypoxia Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Positive Regulation Of Mitochondrial Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Mitochondrial Fission Cellular Response To Toxic Substance Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization Mitochondrion To Lysosome Transport Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Histone Deacetylase Activity Regulation Of Synaptic Vesicle Transport Negative Regulation Of Autophagosome Assembly Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Oxidative Stress-induced Cell Death Negative Regulation Of Oxidative Stress-induced Neuron Death Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Positive Regulation Of Cristae Formation Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Free Ubiquitin Chain Polymerization Positive Regulation Of NMDA Glutamate Receptor Activity Cellular Response To Hydrogen Sulfide Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of ATP Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Lipid Metabolic Process Mitochondrion Organization Branched-chain Amino Acid Catabolic Process Protein Homotetramerization Oxidation-reduction Process Mitochondrial TRNA Methylation Mitochondrial TRNA Processing Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing
Pathways		Pink/Parkin Mediated Mitophagy FOXO-mediated transcription of cell death genes	tRNA processing in the mitochondrion tRNA modification in the mitochondrion Branched-chain amino acid catabolism rRNA processing in the mitochondrion
Drugs			NADH 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct
Diseases		Parkinson's disease (PD)	2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Household income (MTAG) ( 31844048) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Paclitaxel disposition in epithelial ovarian cancer ( 29367611)	Bipolar disorder ( 31043756) Body mass index ( 28892062)
Interacting Genes		18 interacting genes: APPL2 BAG2 BAG5 CRLS1 DNM1L FBXO7 HSD17B10 HSH2D MAP3K7 MARK2 PARK7 PRKACA SNCAIP STAT3 TGM2 TRAF6 UBC UBE2M	31 interacting genes: ALDH3B1 ALDOA APP ATP5F1A CHD3 CPS1 CS ETFDH FAF1 GLUD1 GLUL HADHA HADHB HMGCL HMGCS2 HTRA2 MDH1 OGDH PDHA1 PDHB PDHX PINK1 PRKN PYGL TOMM20 TOMM22 TOMM40 TRAF3IP2 TRAF5 TRAF6 UBE2D1
Entrez ID		65018	3028
HPRD ID		10514	02223
Ensembl ID		ENSG00000158828	ENSG00000072506
Uniprot IDs		Q9BXM7	A0A0S2Z410 Q99714
PDB IDs			1F67 1SO8 1U7T 2O23
Enriched GO Terms of Interacting Partners?
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