ISL2 and LHX3

Number of citations of the paper that reports this interaction (PubMedID 9452425)
54

Data Source:
HPRD (in vitro, in vivo)

		ISL2	LHX3
Description		ISL LIM homeobox 2	LIM homeobox 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Nuclear Chromatin Nucleus Transcription Factor Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Axonogenesis Spinal Cord Motor Neuron Cell Fate Specification Visceral Motor Neuron Differentiation Retinal Ganglion Cell Axon Guidance Negative Regulation Of Neuron Differentiation Neuron Fate Specification Neuron Development Peripheral Nervous System Neuron Development	Placenta Development Motor Neuron Axon Guidance Animal Organ Morphogenesis Spinal Cord Motor Neuron Cell Fate Specification Ventral Spinal Cord Interneuron Specification Medial Motor Column Neuron Differentiation Spinal Cord Association Neuron Differentiation Pituitary Gland Development Neuron Differentiation Lung Development Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development
Pathways			Regulation of expression of SLITs and ROBOs
Drugs
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31015462)	Atrial fibrillation ( 30061737) Crohn's disease ( 28067908) Free thyroxine concentration ( 25743335) Height ( 28552196 20189936) Inflammatory bowel disease ( 28067908) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 28166213 26635082) Thyroid hormone levels ( 23408906) Ulcerative colitis ( 28067908)
Interacting Genes		2 interacting genes: ISL1 LHX3	8 interacting genes: CITED2 IFT172 ISL1 ISL2 LDB1 LHX1 LMX1A RLIM
Entrez ID		64843	8022
HPRD ID		11053	02783
Ensembl ID		ENSG00000159556	ENSG00000107187
Uniprot IDs		Q96A47	F1T0D5 F1T0D9 Q9UBR4
PDB IDs
Enriched GO Terms of Interacting Partners?
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