SH3GL1 and DPPA4

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		SH3GL1	DPPA4
Description		SH3 domain containing GRB2 like 1, endophilin A2	developmental pluripotency associated 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Podosome Cytoplasm Cytosol Cell Junction Early Endosome Membrane Cell Projection Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Nucleoplasm
	Molecular Function	Protein Binding Protein C-terminus Binding Lipid Binding SH3 Domain Binding Phosphatase Binding Beta-1 Adrenergic Receptor Binding Identical Protein Binding Ion Channel Binding Cadherin Binding GTPase Binding	Chromatin Binding Protein Binding
	Biological Process	Signal Transduction Central Nervous System Development Synaptic Vesicle Uncoating Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Vesicle Endocytosis	Somatic Stem Cell Population Maintenance Lung-associated Mesenchyme Development
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs
Diseases
GWAS			Cardiac hypertrophy ( 21348951) Corneal astigmatism ( 23761726) Metabolite levels ( 23823483)
Interacting Genes		27 interacting genes: ARHGAP8 AXIN1 B3GAT1 CREBBP DNM1 DNM1L DPPA4 DPYSL4 FAM102A FBXO32 GPKOW ITCH ITSN2 LRRK2 MAL2 MTA1 PDCD6IP PML PTPRO SEPTIN8 SH2D4A SH3D19 SH3GL3 SYNJ1 VIM VPS37C YWHAZ	18 interacting genes: BTBD2 CRK DPPA2 EIF4A2 EMD GRB2 HTT LDOC1 MAPK6 PLEKHF2 PTPRO QARS1 RPGRIP1 RPS6KB1 SH3GL1 SH3GL2 SH3GL3 VIM
Entrez ID		6455	55211
HPRD ID		03462	16836
Ensembl ID		ENSG00000141985	ENSG00000121570
Uniprot IDs		Q6FGM0 Q99961	Q7L190
PDB IDs
Enriched GO Terms of Interacting Partners?
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