BLK and CTR9

Number of citations of the paper that reports this interaction (PubMedID 8636124)
8

Data Source:
HPRD (in vitro)

		BLK	CTR9
Description		BLK proto-oncogene, Src family tyrosine kinase	CTR9 homolog, Paf1/RNA polymerase II complex component
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Nucleoplasm Cdc73/Paf1 Complex Nuclear Speck Transcriptionally Active Chromatin
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding	RNA Polymerase II Complex Binding Protein Binding SH2 Domain Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Insulin Secretion Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Commitment Inner Cell Mass Cell Differentiation Trophectodermal Cell Differentiation Blastocyst Growth Blastocyst Hatching Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter JAK-STAT Cascade Histone Monoubiquitination Wnt Signaling Pathway Protein Ubiquitination Stem Cell Population Maintenance Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Interleukin-6-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Histone H3-K4 Trimethylation Negative Regulation Of MRNA Polyadenylation Regulation Of Genetic Imprinting Positive Regulation Of Histone H3-K79 Methylation Positive Regulation Of Histone H2B Ubiquitination
Pathways		RUNX1 regulates transcription of genes involved in BCR signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases		Maturity onset diabetes of the young (MODY)
GWAS		Age at first sexual intercourse ( 27089180) Albumin-globulin ratio ( 29403010) Barrett's esophagus ( 27527254) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Diastolic blood pressure ( 27841878 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Estimated glomerular filtration rate ( 31152163) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Immune response to smallpox vaccine (IL-6) ( 22610502) Kawasaki disease ( 22446961 22446962) Neurofibrillary tangles ( 31497858) Non-albumin protein levels ( 29403010) Number of sexual partners ( 30643258) Periodontitis (CDC/AAP) ( 24024966) Phosphatidylcholine levels ( 31551469) Polymyositis ( 26362759) Pulse pressure ( 27841878) Rheumatoid arthritis ( 21452313 30423114 23143596 24390342 19503088) Rheumatoid arthritis (ACPA-positive) ( 24532676) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 27399966 23273568 26663301 23053960 26316170 26502338 18204098 21408207 19165918 28714469 19838193 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 31672989 29293537) Systolic blood pressure ( 28135244 27841878 28739976 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Migraine ( 27182965)
Interacting Genes		18 interacting genes: BCAS2 BCL2 BCL2L1 BCR CBL CCDC33 CD79A CD79B CTR9 EFS ERBB2 FBXO7 FCGR2A FCGR2B PLCG2 SKAP2 STAT3 UBE3A	6 interacting genes: BLK CNTNAP2 H1-2 SMAD9 SOX4 TCEA1
Entrez ID		640	9646
HPRD ID		01866	06717
Ensembl ID		ENSG00000136573	ENSG00000198730
Uniprot IDs		E9PJX5 P51451 Q05D26	Q6PD62
PDB IDs			5ZYQ 6GMH
Enriched GO Terms of Interacting Partners?
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