S100A9 and NCF2

Number of citations of the paper that reports this interaction (PubMedID 15642721)
46

Data Source:
BioGRID (pull down)

		S100A9	NCF2
Description		S100 calcium binding protein A9	neutrophil cytosolic factor 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Junction Secretory Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome	Acrosomal Vesicle Cell Nucleolus Cytosol Membrane Phagolysosome NADPH Oxidase Complex
	Molecular Function	Calcium Ion Binding Protein Binding Microtubule Binding Zinc Ion Binding Antioxidant Activity Toll-like Receptor 4 Binding Arachidonic Acid Binding RAGE Receptor Binding	Protein Binding Protein C-terminus Binding Electron Transfer Activity Superoxide-generating NADPH Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity Rac GTPase Binding
	Biological Process	Cytokine Production Toll-like Receptor Signaling Pathway Leukocyte Migration Involved In Inflammatory Response Autophagy Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Cell-cell Signaling Positive Regulation Of Neuron Projection Development Antimicrobial Humoral Response Positive Regulation Of Cell Growth Neutrophil Chemotaxis Sequestering Of Zinc Ion Chemokine Production Peptidyl-cysteine S-trans-nitrosylation Modification Of Morphology Or Physiology Of Other Organism Defense Response To Bacterium Neutrophil Degranulation Innate Immune Response Positive Regulation Of Inflammatory Response Defense Response To Fungus Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytoskeleton Organization Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Neutrophil Aggregation Cellular Oxidant Detoxification Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Superoxide Metabolic Process Phagocytosis Cellular Defense Response Electron Transport Chain Cellular Response To Oxidative Stress Superoxide Anion Generation Positive Regulation Of Catalytic Activity Innate Immune Response Cell Redox Homeostasis Respiratory Burst Vascular Endothelial Growth Factor Receptor Signaling Pathway Oxidation-reduction Process
Pathways		RHO GTPases Activate NADPH Oxidases Regulation of TLR by endogenous ligand Neutrophil degranulation Metal sequestration by antimicrobial proteins	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases
Drugs		Calcium Zinc	Dextromethorphan
Diseases			Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS		Asthma ( 31619474) Matrix metalloproteinase-8 levels ( 29212897)	Celiac disease and Rheumatoid arthritis ( 26546613) Systemic lupus erythematosus ( 27399966 26606652 26502338 28714469 19838195) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
Interacting Genes		9 interacting genes: CDC42 EGFR MAPK14 NCF2 PTEN S100A8 TUBA1A TUBB USP13	14 interacting genes: AKT1 CDC42 CYBA CYBB GOLGA2 KIFAP3 NCF4 PRDX6 PRKDC RAC1 RAC2 S100A8 S100A9 SYTL1
Entrez ID		6280	4688
HPRD ID		00472	01991
Ensembl ID		ENSG00000163220	ENSG00000116701
Uniprot IDs		P06702	A0A0S2Z457 P19878
PDB IDs		1IRJ 1XK4 4GGF 4XJK 5I8N 5W1F 6DS2	1E96 1HH8 1K4U 1OEY 1WM5 2DMO
Enriched GO Terms of Interacting Partners?
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