CLIP1 and IQGAP1

Number of citations of the paper that reports this interaction (PubMedID 12110184)
210

Data Source:
HPRD (in vivo, in vitro)

		CLIP1	IQGAP1
Description		CAP-Gly domain containing linker protein 1	IQ motif containing GTPase activating protein 1
Image
GO Annotations	Cellular Component	Kinetochore Ruffle Nuclear Envelope Centrosome Cytosol Microtubule Cytoplasmic Microtubule Intermediate Filament Microtubule Cytoskeleton Cytoplasmic Vesicle Membrane Microtubule Plus-end Macropinosome	Ruffle Nucleus Cytoplasm Cytosol Microtubule Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Microtubule Cytoskeleton Lateral Plasma Membrane Axon Growth Cone Midbody Secretory Granule Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Slit Diaphragm Cytoplasmic Ribonucleoprotein Granule Neuron Projection Membrane Raft Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Protein Binding Microtubule Binding Zinc Ion Binding Tubulin Binding Microtubule Plus-end Binding	GTPase Inhibitor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Small GTPase Binding Protein Serine/threonine Kinase Activator Activity S100 Protein Binding Protein-containing Complex Binding Cadherin Binding Rac GTPase Binding Mitogen-activated Protein Kinase Binding Molecular Adaptor Activity
	Biological Process	Mitotic Cell Cycle Microtubule Bundle Formation Positive Regulation Of Microtubule Polymerization Protein Transport Into Plasma Membrane Raft	Regulation Of Cytokine Production Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Fibroblast Growth Factor Receptor Signaling Pathway Viral Process Cell Migration Negative Regulation Of GTPase Activity Negative Regulation Of Dephosphorylation Cellular Response To Platelet-derived Growth Factor Stimulus Neutrophil Degranulation Positive Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Focal Adhesion Assembly Cellular Response To Calcium Ion Cellular Response To Epidermal Growth Factor Stimulus Glomerular Visceral Epithelial Cell Development Positive Regulation Of Dendrite Development Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cellular Protein Localization Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Neuron Projection Extension Response To Angiotensin
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases activate IQGAPs RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Nephrin family interactions Glucagon-like Peptide-1 (GLP1) regulates insulin secretion RHO GTPases activate IQGAPs MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs			Artenimol
Diseases
GWAS		Body mass index ( 26961502 25673413) Chronotype ( 30696823) Hip circumference ( 25673412) Weight ( 28552196)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Heel bone mineral density ( 30598549) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Male-pattern baldness ( 28196072) Multiple sclerosis ( 24076602) White blood cell count (basophil) ( 27863252)
Interacting Genes		11 interacting genes: BIN1 CALM1 CLASP2 DCTN1 IQGAP1 MAPRE2 MTOR PAFAH1B1 TSC22D2 TUBA1A TUBB	29 interacting genes: ACTA1 AIMP1 AKAP5 APC CALM1 CDC42 CDH1 CLIC5 CLIP1 CTNNB1 CYBB EGFR EZR GRIA4 KDR MAPK1 MEN1 MYL1 NPHS1 PDLIM7 PRKACA PTPRM RAC1 S100B STAU1 TSG101 UBE2I VASP YWHAQ
Entrez ID		6249	8826
HPRD ID		01568	04541
Ensembl ID		ENSG00000130779	ENSG00000140575
Uniprot IDs		A0A024RBR1 B3KXA5 P30622	A0A024RC65 P46940
PDB IDs		2CP5 2CP6 2E3H 2E3I 2E4H 2HQH 2QK0 3E2U 3RDV	1X0H 2RR8 3FAY 3I6X 5L0O
Enriched GO Terms of Interacting Partners?
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